{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shan NL"],"funding":["National Institute of Environmental Health Sciences","NCCIH NIH HHS","NIEHS NIH HHS","NCI NIH HHS","National Center for Complementary and Integrative Health of the NIH"],"pagination":["673-686"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7415686"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(8)"],"pubmed_abstract":["Ductal carcinoma <i>in situ</i> (DCIS), which accounts for one out of every five new breast cancer diagnoses, will progress to potentially lethal invasive ductal carcinoma (IDC) in about 50% of cases. Vitamin D compounds have been shown to inhibit progression to IDC in the MCF10DCIS model. This inhibition appears to involve a reduction in the cancer stem cell-like population in MCF10DCIS tumors. To identify genes that are involved in the vitamin D effects, a global transcriptomic analysis was undertaken of MCF10DCIS cells grown in mammosphere cultures, in which cancer stem-like cells grow preferentially and produce colonies by self-renewal and maturation, in the presence and absence of 1α25(OH)<sub>2</sub>D<sub>3</sub> and a vitamin D analog, BXL0124. Using next-generation RNA-sequencing, "],"journal":["Cancer prevention research (Philadelphia, Pa.)"],"pubmed_title":["Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma <i>In Situ</i> by Vitamin D Compounds."],"pmcid":["PMC7415686"],"funding_grant_id":["R01 AT009152","ES005022","R01 CA127645","P30 ES005022","R01 AT007036"],"pubmed_authors":["Furmanski P","Cheng D","Li SN","Sargsyan D","Maehr H","Wernyj R","Kuo HD","Cai L","Kong AN","Minden A","Bak MJ","Wu R","Shan NL","Fang M","Suh N"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma <i>In Situ</i> by Vitamin D Compounds.","description":"Ductal carcinoma <i>in situ</i> (DCIS), which accounts for one out of every five new breast cancer diagnoses, will progress to potentially lethal invasive ductal carcinoma (IDC) in about 50% of cases. Vitamin D compounds have been shown to inhibit progression to IDC in the MCF10DCIS model. This inhibition appears to involve a reduction in the cancer stem cell-like population in MCF10DCIS tumors. To identify genes that are involved in the vitamin D effects, a global transcriptomic analysis was undertaken of MCF10DCIS cells grown in mammosphere cultures, in which cancer stem-like cells grow preferentially and produce colonies by self-renewal and maturation, in the presence and absence of 1α25(OH)<sub>2</sub>D<sub>3</sub> and a vitamin D analog, BXL0124. Using next-generation RNA-sequencing, ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-05-03T04:59:02.586Z","creation":"2021-02-21T05:14:11Z"},"accession":"S-EPMC7415686","cross_references":{"pubmed":["32467291"],"doi":["10.1158/1940-6207.capr-19-0566","10.1158/1940-6207.CAPR-19-0566"]}}