{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cho YM"],"funding":["Intramural NIH HHS","CURE, Citizens United for Research in Epilepsy","NCI NIH HHS"],"pagination":["1746-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7417080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(16)"],"pubmed_abstract":["BACKGROUND:Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for PC, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies, but their role in PC has not yet been investigated. METHODS:We compared the relative radiosensitivity of isolated CSCs to the total population of their corresponding cell lines, and examined the relative numbers of CSCs in irradiated cell lines following long-term recovery and in recurrent human PC. RESULTS:Here, we show that while irradiation does not immediately favor increased survival of CSCs, irradiated PC cell lines showed an increase in CSC properties with long-term recovery. These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth. CONCLUSIONS:The combination of radiotherapy with a CSC-targeted therapeutic strategy may prevent tumor recurrence."],"journal":["The Prostate"],"pubmed_title":["Long-term recovery of irradiated prostate cancer increases cancer stem cells."],"pmcid":["PMC7417080"],"funding_grant_id":["N01CO12400","Z01 BC010794-01","ZIA BC010794-04","N01-CO-12400","Z01 BC010794","ZIA BC010794"],"pubmed_authors":["Kang MJ","Hurt EM","Cho YM","Farrar WL","Kim YS"],"additional_accession":[]},"is_claimable":false,"name":"Long-term recovery of irradiated prostate cancer increases cancer stem cells.","description":"BACKGROUND:Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for PC, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies, but their role in PC has not yet been investigated. METHODS:We compared the relative radiosensitivity of isolated CSCs to the total population of their corresponding cell lines, and examined the relative numbers of CSCs in irradiated cell lines following long-term recovery and in recurrent human PC. RESULTS:Here, we show that while irradiation does not immediately favor increased survival of CSCs, irradiated PC cell lines showed an increase in CSC properties with long-term recovery. These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth. CONCLUSIONS:The combination of radiotherapy with a CSC-targeted therapeutic strategy may prevent tumor recurrence.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Dec","modification":"2020-09-18T07:06:29Z","creation":"2020-08-15T07:05:37Z"},"accession":"S-EPMC7417080","cross_references":{"pubmed":["22513891"],"doi":["10.1002/pros.22527"]}}