biostudies-literatureGiebel CMNIA NIH HHSprogramme development grantsnational institutes of healthnational institute for health research collaboration for leadership in applied health research and care north west coast66-75https://www.ebi.ac.uk/biostudies/studies/S-EPMC7423644biostudies-literatureUnknown34(1)<h4>Background</h4>Different dementia syndromes display different patterns of everyday functioning. This article explored different patterns of functioning at baseline and trajectories of change in behavioral variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD).<h4>Methods</h4>Data from the Uniform Data Set of the National Alzheimer's Coordinating Centre were employed. The Functional Assessment Questionnaire assessed functioning at up to 7 follow-up visits. Independent <i>t</i> tests assessed variations in functioning between syndromes at baseline. Linear mixed-effect modeling explored longitudinal functional trajectories between syndromes.<h4>Results</h4>Data from 3351 patients (306 bvFTD and 3,045AD) were analyzed. At baseline, patients with bvFTD performed all daily activities poorer than AD dementia. Linear mixed models showed a significant effect of syndrome and time on functioning, and evidence of interaction between syndrome and time, with bvFTD showing a steeper decline for using the stove and travel.<h4>Conclusions</h4>Findings can help in the effective care planning of everyday functioning for bvFTD and AD dementia.Journal of geriatric psychiatry and neurologyDistinguishing Frontotemporal Dementia From Alzheimer Disease Through Everyday Function Profiles: Trajectories of Change.PMC7423644P30 AG013846P30 AG028383P30 AG008017P30 AG010133P50 AG005146P50 AG033514P50 AG005681P50 AG005142P30 AG062715P30 AG019610P30 AG066444P50 AG023501P30 AG008051P30 AG010129P30 AG013854P50 AG005138P50 AG008702P30 AG010124P30 AG012300P50 AG005134P50 AG025688U01 AG016976P50 AG005136P30 AG035982P30 AG010161P50 AG005131P50 AG005133P50 AG016574U24 AG072122P50 AG016573P50 AG16574P50 AG016570Giebel CMKnopman DMioshi EKhondoker MfalseDistinguishing Frontotemporal Dementia From Alzheimer Disease Through Everyday Function Profiles: Trajectories of Change.<h4>Background</h4>Different dementia syndromes display different patterns of everyday functioning. This article explored different patterns of functioning at baseline and trajectories of change in behavioral variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD).<h4>Methods</h4>Data from the Uniform Data Set of the National Alzheimer's Coordinating Centre were employed. The Functional Assessment Questionnaire assessed functioning at up to 7 follow-up visits. Independent <i>t</i> tests assessed variations in functioning between syndromes at baseline. Linear mixed-effect modeling explored longitudinal functional trajectories between syndromes.<h4>Results</h4>Data from 3351 patients (306 bvFTD and 3,045AD) were analyzed. At baseline, patients with bvFTD performed all daily activities poorer than AD dementia. Linear mixed models showed a significant effect of syndrome and time on functioning, and evidence of interaction between syndrome and time, with bvFTD showing a steeper decline for using the stove and travel.<h4>Conclusions</h4>Findings can help in the effective care planning of everyday functioning for bvFTD and AD dementia.2021-01-01T00:00:00Z2021 Jan2024-11-21T02:39:35.186Z2021-02-20T17:19:40ZS-EPMC74236443205437610.1177/0891988720901791