{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(2)"],"submitter":["Ugalde CL"],"funding":["Catherine and Michael Heagerty","National Health and Medical Research Council"],"pubmed_abstract":["Astrocytes are glial cells of the central nervous system that become reactive under conditions of stress. The functional properties of reactive astrocytes depend on their stimulus that induces the upregulation of specific genes. Reactive astrocytes are a neuropathological feature of prion disorders; however, their role in the disease pathogenesis is not well understood. Here, we describe our studies of one polarization state of reactive astrocytes, termed A1 astrocytes, in the frontal cortex region of 35 human sporadic Creutzfeldt-Jakob disease brains encompassing a range of molecular sub-types. Examination of two mRNA markers of A1 astrocytes, C3 and GBP2, revealed a strong linear correlation between the two following their log-normalization (<i>P</i> = 0.0011). Both markers were found up"],"journal":["Brain communications"],"pagination":["fcaa029"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7425384"],"repository":["biostudies-literature"],"pubmed_title":["Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain."],"pmcid":["PMC7425384"],"pubmed_authors":["Stehmann C","Collins SJ","Ugalde CL","McLean CA","Hill AF","Lewis V","Lawson VA"],"additional_accession":[]},"is_claimable":false,"name":"Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain.","description":"Astrocytes are glial cells of the central nervous system that become reactive under conditions of stress. The functional properties of reactive astrocytes depend on their stimulus that induces the upregulation of specific genes. Reactive astrocytes are a neuropathological feature of prion disorders; however, their role in the disease pathogenesis is not well understood. Here, we describe our studies of one polarization state of reactive astrocytes, termed A1 astrocytes, in the frontal cortex region of 35 human sporadic Creutzfeldt-Jakob disease brains encompassing a range of molecular sub-types. Examination of two mRNA markers of A1 astrocytes, C3 and GBP2, revealed a strong linear correlation between the two following their log-normalization (<i>P</i> = 0.0011). Both markers were found up","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-29T21:50:27.464Z","creation":"2025-05-29T21:50:27.464Z"},"accession":"S-EPMC7425384","cross_references":{"pubmed":["32954317"],"doi":["10.1093/braincomms/fcaa029"]}}