biostudies-literatureUnknown19(1)Marasini BGovernment of Nepal, Ministry of Health and population, Department of Health Services, Epidemiology and Disease Control Division.<h4>Background</h4>Glucose-6-phosphate dehydrogenase (G6PD) deficiency is currently a threat to malaria elimination due to risk of primaquine-induced haemolysis in G6PD deficient individuals. The World Health Organization (WHO) recommends G6PD screening before providing primaquine as a radical treatment against vivax malaria. However, evidence regarding the prevalence and causing mutations of G6PD deficiency in Nepal is scarce.<h4>Methods</h4>A cross-sectional, population-based, prevalence study was carried out from May to October 2016 in 12 malaria-endemic districts of Nepal. The screening survey included 4067 participants whose G6PD status was determined by G6PD Care Start™ rapid diagnostic test and genotyping.<h4>Results</h4>The prevalence of G6PD deficiency at the national level was 3.Malaria journal287https://www.ebi.ac.uk/biostudies/studies/S-EPMC7425560biostudies-literatureG6PD deficiency in malaria endemic areas of Nepal.PMC7425560Koirala DIama SKhanal PGhimire PLal BKNeupane SPenpitchaporn PAcharya SGornsawun GJha SNMagar RGAwasthi KRMarasini BBhandari SBajracharya BChaudhary AKoirala MMahato RKBhattarai RKBancone GAcharya BPThapa SfalseG6PD deficiency in malaria endemic areas of Nepal.<h4>Background</h4>Glucose-6-phosphate dehydrogenase (G6PD) deficiency is currently a threat to malaria elimination due to risk of primaquine-induced haemolysis in G6PD deficient individuals. The World Health Organization (WHO) recommends G6PD screening before providing primaquine as a radical treatment against vivax malaria. However, evidence regarding the prevalence and causing mutations of G6PD deficiency in Nepal is scarce.<h4>Methods</h4>A cross-sectional, population-based, prevalence study was carried out from May to October 2016 in 12 malaria-endemic districts of Nepal. The screening survey included 4067 participants whose G6PD status was determined by G6PD Care Start™ rapid diagnostic test and genotyping.<h4>Results</h4>The prevalence of G6PD deficiency at the national level was 3.2020-01-01T00:00:00Z2020 Aug2026-07-15T23:19:28.19Z2025-04-07T11:42:46.662ZS-EPMC74255603278797010.1186/s12936-020-03359-6