biostudies-literatureUnknown2020Li KMedical Scientific Research Foundation of Guangdong ProvinceTraditional Chinese Medicine Bureau of Guangdong ProvinceOrdinary Colleges and Universities in GuangdongNatural Science Foundation of Guangdong ProvinceAffiliated Hospital of GMUNational Natural Science Foundation of ChinaScience and Technology Planning Project of ZhanjiangGMUGiven the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.Mediators of inflammationhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC7426773biostudies-literatureProtection of Fecal Microbiota Transplantation in a Mouse Model of Multiple SclerosisPMC7426773LCYJ2018A003M2016037BJ2016122019KTSCX045BJ201515814009862018A01021A20202822020A151501128420182074Peng XYin XLi HMai YZhao BLi KLiu ZCao XHuang ZWei SJiang CHu LZhou HMa GfalseProtection of Fecal Microbiota Transplantation in a Mouse Model of Multiple SclerosisGiven the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.2020-01-01T00:00:00Z2020 Jan2020-08-24T07:07:59Z2020-08-24T07:07:59ZS-EPMC7426773