biostudies-literatureKilpi FBritish Heart FoundationNational Institute for Health Research (GB)Medical Research CouncilNational Institute for Health Research (NIHR)Wellcome Trust177https://www.ebi.ac.uk/biostudies/studies/S-EPMC7427852biostudies-literatureUnknown20(1)<h4>Background</h4>There may be changes in cognitive function in women going through the menopause. The current evidence remains unclear, however, whether these changes occur over and above those of general ageing. We aimed to evaluate the potential impact of the menopause (assessed by reproductive age and hormone levels) on cognitive function in women in mid-life accounting for the underlying effects of ageing.<h4>Methods</h4>The study was based on the follow up of women originally enrolled in pregnancy in a birth cohort when resident in the South West of England, UK between 1991 and 1992. Using up to three repeated measurements in 2411 women (mean age 51 at first assessment), we modelled changes in six cognitive function domains: immediate and delayed verbal episodic memory, working memoBMC women's healthChanges in six domains of cognitive function with reproductive and chronological ageing and sex hormones: a longitudinal study in 2411 UK mid-life women.PMC7427852MC_UU_00011/3NF-SI-0616-10102NF-0616-10102SP/07/008/24066G1001357WT092830MMR/M009351/1102215/2/13/2MC_PC_15018MC_UU_00011/6MC_PC_19009Nelson SMLawlor DASoares ALGKilpi FSattar NFraser AFallon SJTilling KfalseChanges in six domains of cognitive function with reproductive and chronological ageing and sex hormones: a longitudinal study in 2411 UK mid-life women.<h4>Background</h4>There may be changes in cognitive function in women going through the menopause. The current evidence remains unclear, however, whether these changes occur over and above those of general ageing. We aimed to evaluate the potential impact of the menopause (assessed by reproductive age and hormone levels) on cognitive function in women in mid-life accounting for the underlying effects of ageing.<h4>Methods</h4>The study was based on the follow up of women originally enrolled in pregnancy in a birth cohort when resident in the South West of England, UK between 1991 and 1992. Using up to three repeated measurements in 2411 women (mean age 51 at first assessment), we modelled changes in six cognitive function domains: immediate and delayed verbal episodic memory, working memo2020-01-01T00:00:00Z2020 Aug2025-06-01T01:17:43.207Z2025-06-01T01:17:43.207ZS-EPMC74278523279528110.1186/s12905-020-01040-3