{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(9)"],"submitter":["Wada H"],"pubmed_abstract":["Background VEGF-D (vascular endothelial growth factor D) and VEGF-C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms. We recently demonstrated that the serum VEGF-C level is inversely and independently associated with all-cause mortality in patients with suspected or known coronary artery disease. We investigated whether VEGF-D had distinct relationships with mortality and cardiovascular events in those patients. Methods and Results We performed a multicenter, prospective cohort study of 2418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. The serum level of VEGF-D was measured. The primary outcome was all-cause d"],"journal":["Journal of the American Heart Association"],"pagination":["e015761"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7428571"],"repository":["biostudies-literature"],"pubmed_title":["Distinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease."],"pmcid":["PMC7428571"],"pubmed_authors":["Yonezawa K","Shimizu M","Suzuki M","Sakagami S","Morita Y","Funada J","Shimatsu A","Shinozaki T","Takagi D","Iguchi M","Akao M","Matsuda M","Takenaka T","Satoh-Asahara N","Unoki T","ANOX Study Investigators","Hasegawa K","Kotani K","Ishii M","Ajiro Y","Yamakage H","Wada K","Kusakabe T","Kato T","Fujimoto K","Wada M","Yasoda A","Masunaga N","Abe M","Wada H","Nakamura T","Matsubara H"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease.","description":"Background VEGF-D (vascular endothelial growth factor D) and VEGF-C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms. We recently demonstrated that the serum VEGF-C level is inversely and independently associated with all-cause mortality in patients with suspected or known coronary artery disease. We investigated whether VEGF-D had distinct relationships with mortality and cardiovascular events in those patients. Methods and Results We performed a multicenter, prospective cohort study of 2418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. The serum level of VEGF-D was measured. The primary outcome was all-cause d","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-18T14:54:47.14Z","creation":"2025-04-07T01:17:09.79Z"},"accession":"S-EPMC7428571","cross_references":{"pubmed":["32319336"],"doi":["10.1161/JAHA.119.015761"]}}