biostudies-literatureUnknown9(9)Wada HBackground VEGF-D (vascular endothelial growth factor D) and VEGF-C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms. We recently demonstrated that the serum VEGF-C level is inversely and independently associated with all-cause mortality in patients with suspected or known coronary artery disease. We investigated whether VEGF-D had distinct relationships with mortality and cardiovascular events in those patients. Methods and Results We performed a multicenter, prospective cohort study of 2418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. The serum level of VEGF-D was measured. The primary outcome was all-cause dJournal of the American Heart Associatione015761https://www.ebi.ac.uk/biostudies/studies/S-EPMC7428571biostudies-literatureDistinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease.PMC7428571Yonezawa KShimizu MSuzuki MSakagami SMorita YFunada JShimatsu AShinozaki TTakagi DIguchi MAkao MMatsuda MTakenaka TSatoh-Asahara NUnoki TANOX Study InvestigatorsHasegawa KKotani KIshii MAjiro YYamakage HWada KKusakabe TKato TFujimoto KWada MYasoda AMasunaga NAbe MWada HNakamura TMatsubara HfalseDistinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease.Background VEGF-D (vascular endothelial growth factor D) and VEGF-C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms. We recently demonstrated that the serum VEGF-C level is inversely and independently associated with all-cause mortality in patients with suspected or known coronary artery disease. We investigated whether VEGF-D had distinct relationships with mortality and cardiovascular events in those patients. Methods and Results We performed a multicenter, prospective cohort study of 2418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. The serum level of VEGF-D was measured. The primary outcome was all-cause d2020-01-01T00:00:00Z2020 May2025-04-18T14:54:47.14Z2025-04-07T01:17:09.79ZS-EPMC74285713231933610.1161/JAHA.119.015761