{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pierce JB"],"funding":["NHLBI NIH HHS"],"pagination":["e015326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7428574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["Background Childhood adversity and trauma have been shown to be associated with poorer cardiovascular disease (CVD) outcomes in adulthood. However, longitudinal studies of this association are rare. Methods and Results Our study used the CARDIA (Coronary Artery Risk Development in Young Adults) Study, a longitudinal cohort that has followed participants from recruitment in 1985-1986 through 2018, to determine how childhood psychosocial environment relates to CVD incidence and all-cause mortality in middle age. Participants (n=3646) completed the Childhood Family Environment (CFE) questionnaire at the year 15 (2000-2001) CARDIA examination and were grouped by high, moderate, or low relative CFE adversity scores. We used sequential multivariable regression models to estimate hazard ratios of"],"journal":["Journal of the American Heart Association"],"pubmed_title":["Association of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence and Mortality in Middle Age."],"pmcid":["PMC7428574"],"funding_grant_id":["HHSN268201800005I","HHSN268201800004I","HHSN268201800007I","HHSN268201800006I","HHSN268201800003I"],"pubmed_authors":["Sidney S","Merkin SS","Kiefe CI","Kershaw KN","Jacobs DR","Pierce JB","Feinglass J"],"additional_accession":[]},"is_claimable":false,"name":"Association of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence and Mortality in Middle Age.","description":"Background Childhood adversity and trauma have been shown to be associated with poorer cardiovascular disease (CVD) outcomes in adulthood. However, longitudinal studies of this association are rare. Methods and Results Our study used the CARDIA (Coronary Artery Risk Development in Young Adults) Study, a longitudinal cohort that has followed participants from recruitment in 1985-1986 through 2018, to determine how childhood psychosocial environment relates to CVD incidence and all-cause mortality in middle age. Participants (n=3646) completed the Childhood Family Environment (CFE) questionnaire at the year 15 (2000-2001) CARDIA examination and were grouped by high, moderate, or low relative CFE adversity scores. We used sequential multivariable regression models to estimate hazard ratios of","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-18T14:54:48.1Z","creation":"2025-04-07T01:17:11.169Z"},"accession":"S-EPMC7428574","cross_references":{"pubmed":["32342717"],"doi":["10.1161/JAHA.119.015326"]}}