{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(7)"],"submitter":["Han BH"],"pubmed_abstract":["Background A low level of high-density lipoprotein-cholesterol (HDL-C) is a well-known risk factor for cardiovascular events. Recent studies have also suggested that HDL-C variability has a predictive role in patients with coronary artery disease. We investigated the combined effect of the mean and variability of HDL-C on the risk of myocardial infarction (MI), stroke, and mortality in the general population. Methods and Results We selected 5 433 098 subjects in the Korean National Health Insurance System cohort who had no history of MI or stroke and who underwent ≥3 health examinations between 2009 and 2013. Visit-to-visit HDL-C variability was calculated using the coefficient of variation, variability independent of the mean and average real variability. The low-mean and high-variability"],"journal":["Journal of the American Heart Association"],"pagination":["e015493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7428592"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Mean and Variability of High-Density Lipoprotein-Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population."],"pmcid":["PMC7428592"],"pubmed_authors":["Han K","Han BH","Lee SH","Kim MK","Yoon KH"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Mean and Variability of High-Density Lipoprotein-Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population.","description":"Background A low level of high-density lipoprotein-cholesterol (HDL-C) is a well-known risk factor for cardiovascular events. Recent studies have also suggested that HDL-C variability has a predictive role in patients with coronary artery disease. We investigated the combined effect of the mean and variability of HDL-C on the risk of myocardial infarction (MI), stroke, and mortality in the general population. Methods and Results We selected 5 433 098 subjects in the Korean National Health Insurance System cohort who had no history of MI or stroke and who underwent ≥3 health examinations between 2009 and 2013. Visit-to-visit HDL-C variability was calculated using the coefficient of variation, variability independent of the mean and average real variability. The low-mean and high-variability","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-18T14:54:55.966Z","creation":"2025-04-07T01:17:45.927Z"},"accession":"S-EPMC7428592","cross_references":{"pubmed":["32248727"],"doi":["10.1161/JAHA.119.015493"]}}