biostudies-literatureUnknown9(7)Chandiramani RBackground Women have been associated with higher rates of recurrent events after percutaneous coronary intervention than men, possibly attributable to advanced age at presentation and greater comorbidities. These factors also put women at higher risk of bleeding, which may influence therapeutic strategies and clinical outcomes. Methods and Results We performed a patient-level pooled analysis of 4 postapproval registries to evaluate sex-related differences in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention. HBR required fulfillment of at least 1 major or 2 minor criteria of the Academic Research Consortium definition. Outcomes of interest were major bleeding and major adverse cardiac events (composite of cardiac death, myocardial infarction, or definite/pJournal of the American Heart Associatione014611https://www.ebi.ac.uk/biostudies/studies/S-EPMC7428610biostudies-literatureSex-Related Differences in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: A Patient-Level Pooled Analysis From 4 Postapproval Studies.PMC7428610Krucoff MKozuma KSeth ASaito SNeumann FJBlum MCao DMakkar RHermiller JRoumeliotis AGe JClaessen BEWang JChandiramani RSorrentino SGoel RAngiolillo DJRuster KValgimigli MBangalore SGuedeney PMehran RBhatt DLfalseSex-Related Differences in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: A Patient-Level Pooled Analysis From 4 Postapproval Studies.Background Women have been associated with higher rates of recurrent events after percutaneous coronary intervention than men, possibly attributable to advanced age at presentation and greater comorbidities. These factors also put women at higher risk of bleeding, which may influence therapeutic strategies and clinical outcomes. Methods and Results We performed a patient-level pooled analysis of 4 postapproval registries to evaluate sex-related differences in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention. HBR required fulfillment of at least 1 major or 2 minor criteria of the Academic Research Consortium definition. Outcomes of interest were major bleeding and major adverse cardiac events (composite of cardiac death, myocardial infarction, or definite/p2020-01-01T00:00:00Z2020 Apr2025-04-18T14:55:04.156Z2025-04-07T01:18:53.687ZS-EPMC74286103222339610.1161/JAHA.119.014611