{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Slominski RM"],"funding":["BLRD VA","NIAID NIH HHS","NIMHD NIH HHS","VA","NIAMS NIH HHS","NIH HHS"],"pagination":["885-890"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7436895"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(9)"],"pubmed_abstract":["The negative outcomes of COVID-19 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a \"cytokine storm\" and to the attendant oxidative stress. Active hydroxyl forms of vitamin D are anti-inflammatory, induce antioxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol and the CYP11A1-generated non-calcemic hydroxyderivatives. They inhibit the production of pro-inflammatory cytokines, downregulate NF-κΒ, show inverse agonism on RORγ and counteract oxidative stress through the activation of NRF-2. Therefore, a direct delivery of hydroxyderivatives of vitamin D deserves consideration in the treatment of COVID-19 or ARDS of different aetiology. We also recommend treatment of COVID-19 patients with "],"journal":["Experimental dermatology"],"pubmed_title":["COVID-19 and Vitamin D: A lesson from the skin."],"pmcid":["PMC7436895"],"funding_grant_id":["R01 AR073004","R01 AR071189","R21 AI149267","1R21AI149267-01A1","1R01AR073004","R21 MD015319","1I01BX004293-01A1","I01 BX004293","R01AR071189"],"pubmed_authors":["Stefan J","Slominski AT","Raman C","Athar M","Jetten AM","Holick MF","Slominski RM"],"additional_accession":[]},"is_claimable":false,"name":"COVID-19 and Vitamin D: A lesson from the skin.","description":"The negative outcomes of COVID-19 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a \"cytokine storm\" and to the attendant oxidative stress. Active hydroxyl forms of vitamin D are anti-inflammatory, induce antioxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol and the CYP11A1-generated non-calcemic hydroxyderivatives. They inhibit the production of pro-inflammatory cytokines, downregulate NF-κΒ, show inverse agonism on RORγ and counteract oxidative stress through the activation of NRF-2. Therefore, a direct delivery of hydroxyderivatives of vitamin D deserves consideration in the treatment of COVID-19 or ARDS of different aetiology. We also recommend treatment of COVID-19 patients with ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-02T22:18:18.034Z","creation":"2022-07-19T07:47:22.391Z"},"accession":"S-EPMC7436895","cross_references":{"pubmed":["32779213"],"doi":["10.1111/exd.14170"]}}