biostudies-literatureLook AHEAD Research GroupNIDDK NIH HHSNHLBI NIH HHSNINR NIH HHSNIMHD NIH HHSIndian Health ServiceOffice of Research on Women's HealthCDC HHS893-901https://www.ebi.ac.uk/biostudies/studies/S-EPMC7437140biostudies-literatureUnknown28(5)OBJECTIVE:This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group. METHODS:Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012. RESULTS:Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean? (SE) of 1.2 ?(0.2) kg and 1.8? (0.2) kg, respectively (P?=?0.003). In addition, 31% of ILI and 23.9% of DSE participants gained???2% (P?<?0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost???2% of EOI weight (P?=?0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants. CONCLUSIONS:Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained???2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.Obesity (Silver Spring, Md.)Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.PMC7437140U01 DK057182DK57182K23 NR017209DK57008P30 DK111022DK57149DK56992DK57002DK56990U01 DK056992U01 DK056990U01 DK057002U01 DK057008U01 DK057149DK57154U01 DK057171DK57131DK57151U01 DK057131U01 DK057154DK57171U01 DK057151P30 DK017047DK57136DK57135DK57178DK57177DK57078U01 DK057219DK57219U01 DK057135U01 DK057136U01 DK057078U01 DK057177U01 DK057178K23NR017209Neiberg RHPi-Sunyer XPeters AWyatt HMontez MGBlackburn GDelahanty LMLook AHEAD Research GroupBerkowitz RIGay LJJohnson KCSteinburg HZhang PDutton GRJeffery RWHouston DKKahn SERedmon BYanovski SZEvans MGregg EWForeyt JPPownall HBolin PClark JMCurtis JMJakicic JMWalker MCoday MMichalski KLHazuda HPEwing LJHorton ESReboussin DWadden TAHill JOPatricio JRejeski WJChao AMKnowler WCWing RRKure AWilliamson DAfalseWeight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.OBJECTIVE:This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group. METHODS:Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012. RESULTS:Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean? (SE) of 1.2 ?(0.2) kg and 1.8? (0.2) kg, respectively (P?=?0.003). In addition, 31% of ILI and 23.9% of DSE participants gained???2% (P?<?0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost???2% of EOI weight (P?=?0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants. CONCLUSIONS:Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained???2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.2020-01-01T00:00:00Z2020 May2020-11-07T10:13:19Z2020-11-03T08:06:07ZS-EPMC74371403232014410.1002/oby.22769