{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manson JJ"],"funding":["Versus Arthritis","Medical Research Council","National Institute for Health Research (NIHR)","Vivensa Foundation","Rosetrees","Multiple Sclerosis Society","Wellcome Trust","Academy of Medical Sciences"],"pagination":["e594-e602"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7442426"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(10)"],"pubmed_abstract":["Background
A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.Methods
In this retrospective cohort study, we enrolled consecutive inpatients (aged ≥18 years) admitted to University College London Hospitals and Newcastle upon Tyne Hospitals in the UK with PCR-confirmed COVID-19 during the first wave of community-acquired infection. Demographic data, laboratory tests, and clinical status were recorded from the day of admission until death or discharge, with a minimum follow-up time of 28 days. We defined COV-HI as a C-reactive protein "],"journal":["The Lancet. Rheumatology"],"pubmed_title":["COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study."],"pmcid":["PMC7442426"],"funding_grant_id":["21226","MC_PC_15005","RPGF1902/117","211153/Z/18/Z","ACF-2018-01-004","20164","RPGF1902\\117","21593","ACF-2018-01-001","CL-2013-01-003","22203","076","M409-F1","CL-2017-01-004","M409","NIHR-INF-0958","ACF-2016-18-026","AMS-SGCL11-Duncan"],"pubmed_authors":["West J","Mehta P","Rampling T","Tattersall RS","Hanrath AT","J'Bari H","Williams B","Lendrem BC","Robinson GA","Schim van der Loeff I","Naja M","Crooks C","Duncan CJA","De Soyza A","Luintel A","Peckham H","Goulden B","Baker KF","Manson JJ","Ledlie A","Liddle T","Ribeiro Santos L","Khan E","Waddington KE","Marks M","Hawkins E","Collin M","Adeney C","Brown M","Singer M","Snell A","McLoughlin E","Greenwood M","Martin-Gutierrez L","Peng J","Jury EC"],"additional_accession":[]},"is_claimable":false,"name":"COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.","description":"Background
A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.Methods
In this retrospective cohort study, we enrolled consecutive inpatients (aged ≥18 years) admitted to University College London Hospitals and Newcastle upon Tyne Hospitals in the UK with PCR-confirmed COVID-19 during the first wave of community-acquired infection. Demographic data, laboratory tests, and clinical status were recorded from the day of admission until death or discharge, with a minimum follow-up time of 28 days. We defined COV-HI as a C-reactive protein ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-05-03T22:51:57.376Z","creation":"2020-08-29T07:28:18Z"},"accession":"S-EPMC7442426","cross_references":{"pubmed":["32864628"],"doi":["10.1016/S2665-9913(20)30275-7"]}}