biostudies-literatureManson JJVersus ArthritisMedical Research CouncilNational Institute for Health Research (NIHR)Vivensa FoundationRosetreesMultiple Sclerosis SocietyWellcome TrustAcademy of Medical Sciencese594-e602https://www.ebi.ac.uk/biostudies/studies/S-EPMC7442426biostudies-literatureUnknown2(10)<h4>Background</h4>A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.<h4>Methods</h4>In this retrospective cohort study, we enrolled consecutive inpatients (aged ≥18 years) admitted to University College London Hospitals and Newcastle upon Tyne Hospitals in the UK with PCR-confirmed COVID-19 during the first wave of community-acquired infection. Demographic data, laboratory tests, and clinical status were recorded from the day of admission until death or discharge, with a minimum follow-up time of 28 days. We defined COV-HI as a C-reactive protein The Lancet. RheumatologyCOVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.PMC744242621226MC_PC_15005RPGF1902/117211153/Z/18/ZACF-2018-01-00420164RPGF1902\11721593ACF-2018-01-001CL-2013-01-00322203076M409-F1CL-2017-01-004M409NIHR-INF-0958ACF-2016-18-026AMS-SGCL11-DuncanWest JMehta PRampling TTattersall RSHanrath ATJ'Bari HWilliams BLendrem BCRobinson GASchim van der Loeff INaja MCrooks CDuncan CJADe Soyza ALuintel APeckham HGoulden BBaker KFManson JJLedlie ALiddle TRibeiro Santos LKhan EWaddington KEMarks MHawkins ECollin MAdeney CBrown MSinger MSnell AMcLoughlin EGreenwood MMartin-Gutierrez LPeng JJury ECfalseCOVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.<h4>Background</h4>A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.<h4>Methods</h4>In this retrospective cohort study, we enrolled consecutive inpatients (aged ≥18 years) admitted to University College London Hospitals and Newcastle upon Tyne Hospitals in the UK with PCR-confirmed COVID-19 during the first wave of community-acquired infection. Demographic data, laboratory tests, and clinical status were recorded from the day of admission until death or discharge, with a minimum follow-up time of 28 days. We defined COV-HI as a C-reactive protein 2020-01-01T00:00:00Z2020 Oct2026-05-03T22:51:57.376Z2020-08-29T07:28:18ZS-EPMC74424263286462810.1016/S2665-9913(20)30275-7