{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["47(4)"],"submitter":["Gassner C"],"pubmed_abstract":["The U antigen (MNS5) is one of 49 antigens belonging to the MNS blood group system (ISBT002) carried on glycophorins A (GPA) and B (GPB). U is present on the red blood cells in almost all Europeans and Asians but absent in approximately 1.0% of Black Africans. U negativity coincides with negativity for S (MNS3) and s (MNS4) on GPB, thus be called S-s-U-, and is thought to arise from homozygous deletion of <i>GYPB</i>. Little is known about the molecular background of these deletions. Bioinformatic analysis of the 1000 Genomes Project data revealed several candidate regions with apparent deletions in <i>GYPB</i>. Highly specific Gap-PCRs, only resulting in positive amplification from DNAs with deletions present, allowed for the exact genetic localization of 3 different breakpoints; 110.24- "],"journal":["Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie"],"pagination":["326-336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7443675"],"repository":["biostudies-literature"],"pubmed_title":["Two Prevalent ∼100-kb <i>GYPB</i> Deletions Causative of the GPB-Deficient Blood Group MNS Phenotype S-s-U- in Black Africans."],"pmcid":["PMC7443675"],"pubmed_authors":["Just B","Trost N","Frey BM","Forster M","Franke A","Bensing KM","Storry JR","Gassner C","Meyer S","Engstrom C","Denomme GA","Song YL","Jungbauer C","Portmann C","Mattle-Greminger MP"],"additional_accession":[]},"is_claimable":false,"name":"Two Prevalent ∼100-kb <i>GYPB</i> Deletions Causative of the GPB-Deficient Blood Group MNS Phenotype S-s-U- in Black Africans.","description":"The U antigen (MNS5) is one of 49 antigens belonging to the MNS blood group system (ISBT002) carried on glycophorins A (GPA) and B (GPB). U is present on the red blood cells in almost all Europeans and Asians but absent in approximately 1.0% of Black Africans. U negativity coincides with negativity for S (MNS3) and s (MNS4) on GPB, thus be called S-s-U-, and is thought to arise from homozygous deletion of <i>GYPB</i>. Little is known about the molecular background of these deletions. Bioinformatic analysis of the 1000 Genomes Project data revealed several candidate regions with apparent deletions in <i>GYPB</i>. Highly specific Gap-PCRs, only resulting in positive amplification from DNAs with deletions present, allowed for the exact genetic localization of 3 different breakpoints; 110.24- ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-06-02T16:17:55.383Z","creation":"2020-09-05T07:09:35Z"},"accession":"S-EPMC7443675","cross_references":{"pubmed":["32884505"],"doi":["10.1159/000504946"]}}