biostudies-literatureKadosh BSNCATS NIH HHSNHLBI NIH HHS2045-2053https://www.ebi.ac.uk/biostudies/studies/S-EPMC7446967biostudies-literatureUnknown40(9)The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.Arteriosclerosis, thrombosis, and vascular biologyCOVID-19 and the Heart and Vasculature: Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease.PMC7446967R01 HL146206P01 HL131481P01 HL146367R35 HL135799UL1 TR000038UL1 TR001445R01 HL132516K23 HL125991Kadosh BSPillinger MKatz SDMoore KJRamasamy RShah BHochman JGarshick MSGaztanaga JNewman JDReynolds HRFishman GIfalseCOVID-19 and the Heart and Vasculature: Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease.The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.2020-01-01T00:00:00Z2020 Sep2025-04-04T10:00:18.676Z2020-08-31T07:04:38ZS-EPMC74469673268740010.1161/ATVBAHA.120.314513