biostudies-literatureShah SJNational Center for Advancing Translational SciencesNational Institute of Allergy and Infectious DiseasesNCATS NIH HHSNIAID NIH HHSNHLBI NIH HHSNational Heart Lung Blood Institute100518https://www.ebi.ac.uk/biostudies/studies/S-EPMC7447618biostudies-literatureUnknown27<h4>Background</h4>Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses.<h4>Methods</h4>We examined emergency department patients between February 3 and March 31, 2020 with an acute respiratory illness who were tested for SARS-CoV-2. We determined COVID-19 status by PCR and metagenomic next generation sequencing (mNGS). We compared clinical presentation, diagnostics, treatment, and outcomes.<h4>Findings</h4>Among 316 patients, 33 tested positive for SARS-CoV-2; 31 without COVID-19 tested positive for another respiratory virus. Among patients with additional viral testing (27/33), no SARS-CoV-2 co-infections were identified. Compared to those who teEClinicalMedicineClinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.PMC74476181K23HL138461–01A1KL2 TR001870R01-HL105704K24 HL141354T32 AI060530R33-AI120977K23 HL138461KL2TR001870Haliburton JBabik JMSheu JKamm JKerkhoff ADPisco AOSellas ABotvinnik OBPhelps MYu GKumar GRMartinez SPeluso MJAlvarez FNHao SDetweiler AMMick EKistler ADavis JFang MCSpottiswoode NCastaneda GDadasovich RMNeff NPrasad PADeng XCZB CLIAhub ConsortiumDeRisi JLTan MMalcolm KBFederman SAlipanah NSherwood KDKangelaris KNMwakibete LChiu CYLangelier CShah SJLi LMNajafi NMann SABarish PNMary RKRubio LAAbe-Jones YRatnasiri KfalseClinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.<h4>Background</h4>Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses.<h4>Methods</h4>We examined emergency department patients between February 3 and March 31, 2020 with an acute respiratory illness who were tested for SARS-CoV-2. We determined COVID-19 status by PCR and metagenomic next generation sequencing (mNGS). We compared clinical presentation, diagnostics, treatment, and outcomes.<h4>Findings</h4>Among 316 patients, 33 tested positive for SARS-CoV-2; 31 without COVID-19 tested positive for another respiratory virus. Among patients with additional viral testing (27/33), no SARS-CoV-2 co-infections were identified. Compared to those who te2020-01-01T00:00:00Z2020 Oct2025-04-19T04:00:20.988Z2020-08-31T07:04:23ZS-EPMC74476183286458810.1016/j.eclinm.2020.100518