biostudies-literatureCui JNational Natural Science Foundation of ChinaNanjing UniversityZhejiang UniversityNatural Science Foundation of Jiangsu Province189-196https://www.ebi.ac.uk/biostudies/studies/S-EPMC7448882biostudies-literatureUnknown144(4)Pneumonia is a common illness that continues to be the major killer of remaining to be a significant source of morbidity and mortality in the patient population. Many microorganisms cause pneumonia, and now concern is turning to the importance of the cause the new therapies for viral pneumonia. In the current study, we report the effect of andrographolide sulfonate, a water-soluble form of andrographolide (trade name: Xi-Yan-Ping Injection), on poly I: C-induced pneumonia. Andrographolide sulfonate was administrated through intraperitoneal injection to mice with poly I: C-induced pneumonia. Recruitment of airway inflammatory cells, alteration of lung histological induced by Poly I: C were significantly ameliorated by andrographolide sulfonate. The protein levels of pro-inflammatory cytokinJournal of pharmacological sciencesAndrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice.PMC7448882BK201903062020XGZX00781903620817301001438013481922067Li YCui JGuo WXu QQu JGao JSun YFan TLiu WfalseAndrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice.Pneumonia is a common illness that continues to be the major killer of remaining to be a significant source of morbidity and mortality in the patient population. Many microorganisms cause pneumonia, and now concern is turning to the importance of the cause the new therapies for viral pneumonia. In the current study, we report the effect of andrographolide sulfonate, a water-soluble form of andrographolide (trade name: Xi-Yan-Ping Injection), on poly I: C-induced pneumonia. Andrographolide sulfonate was administrated through intraperitoneal injection to mice with poly I: C-induced pneumonia. Recruitment of airway inflammatory cells, alteration of lung histological induced by Poly I: C were significantly ameliorated by andrographolide sulfonate. The protein levels of pro-inflammatory cytokin2020-01-01T00:00:00Z2020 Dec2025-04-05T13:27:10.809Z2020-09-05T07:10:54ZS-EPMC74488823307083710.1016/j.jphs.2020.08.005