{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hutch CR"],"funding":["NIDDK NIH HHS"],"pagination":["509-518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7451489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["271(3)"],"pubmed_abstract":["<h4>Objective</h4>The aim of this study was to determine whether downstream [peroxisome proliferator-activated-receptor alpha (PPARα) and the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements, and diet preference following vertical sleeve gastrectomy (VSG).<h4>Summary background data</h4>OEA is an anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modulate lipid metabolism, insulin secretion, and energy expenditure by activating targets such as PPARα and GPR119.<h4>Methods</h4>Diet-induced obese mice, including wild-type or whole body knockout (KO) of PPARα, GPR119, and CD36, were stratified to either VSG or sham su"],"journal":["Annals of surgery"],"pubmed_title":["Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy."],"pmcid":["PMC7451489"],"funding_grant_id":["R01 DK082480","T32 DK101357"],"pubmed_authors":["Sorrell J","Hutch CR","Obici S","Trakimas DR","Roelofs K","Sandoval DA","Cota D","Pressler J"],"additional_accession":[]},"is_claimable":false,"name":"Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.","description":"<h4>Objective</h4>The aim of this study was to determine whether downstream [peroxisome proliferator-activated-receptor alpha (PPARα) and the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements, and diet preference following vertical sleeve gastrectomy (VSG).<h4>Summary background data</h4>OEA is an anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modulate lipid metabolism, insulin secretion, and energy expenditure by activating targets such as PPARα and GPR119.<h4>Methods</h4>Diet-induced obese mice, including wild-type or whole body knockout (KO) of PPARα, GPR119, and CD36, were stratified to either VSG or sham su","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-04-22T02:11:55.823Z","creation":"2020-08-31T07:08:19Z"},"accession":"S-EPMC7451489","cross_references":{"pubmed":["30702457"],"doi":["10.1097/SLA.0000000000003093","10.1097/sla.0000000000003093"]}}