biostudies-literatureHutch CRNIDDK NIH HHS509-518https://www.ebi.ac.uk/biostudies/studies/S-EPMC7451489biostudies-literatureUnknown271(3)<h4>Objective</h4>The aim of this study was to determine whether downstream [peroxisome proliferator-activated-receptor alpha (PPARα) and the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements, and diet preference following vertical sleeve gastrectomy (VSG).<h4>Summary background data</h4>OEA is an anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modulate lipid metabolism, insulin secretion, and energy expenditure by activating targets such as PPARα and GPR119.<h4>Methods</h4>Diet-induced obese mice, including wild-type or whole body knockout (KO) of PPARα, GPR119, and CD36, were stratified to either VSG or sham suAnnals of surgeryOea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.PMC7451489R01 DK082480T32 DK101357Sorrell JHutch CRObici STrakimas DRRoelofs KSandoval DACota DPressler JfalseOea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.<h4>Objective</h4>The aim of this study was to determine whether downstream [peroxisome proliferator-activated-receptor alpha (PPARα) and the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements, and diet preference following vertical sleeve gastrectomy (VSG).<h4>Summary background data</h4>OEA is an anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modulate lipid metabolism, insulin secretion, and energy expenditure by activating targets such as PPARα and GPR119.<h4>Methods</h4>Diet-induced obese mice, including wild-type or whole body knockout (KO) of PPARα, GPR119, and CD36, were stratified to either VSG or sham su2020-01-01T00:00:00Z2020 Mar2025-04-22T02:11:55.823Z2020-08-31T07:08:19ZS-EPMC74514893070245710.1097/SLA.000000000000309310.1097/sla.0000000000003093