{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lemieux JE"],"funding":["NIAID NIH HHS","NHGRI NIH HHS","NIGMS NIH HHS","NCEZID CDC HHS"],"pubmed_abstract":["SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and analyzed 772 complete SARS-CoV-2 genomes from the region, including nearly all confirmed cases within the first week of the epidemic and hundreds of cases from major outbreaks at a conference, a nursing facility, and among homeless shelter guests and staff. The data reveal over 80 introductions into the Boston area, predominantly from elsewhere in the United States and Europe. We studied two superspreading events covered by the data, events that led to very different outcomes because of the timing and populations involved. One produced rapid"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2020.08.23.20178236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7457619"],"repository":["biostudies-literature"],"pubmed_title":["Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events."],"pmcid":["PMC7457619"],"funding_grant_id":["U01 CK000490","U54 GM088558","R37 AI147868","K99 HG010669","U19 AI110818","R01 AI148784"],"pubmed_authors":["Gallagher GR","Normandin E","Neumann A","Brown CM","Shaw BM","Carter A","Siddle KJ","Hanage WP","Gaeta JM","Schaffner SF","Lin AE","Cerrato F","Tomkins-Tinch CH","Baggett TP","Cusick C","Gladden-Young A","Park DJ","Myhrvold C","Maclnnis BL","Hooper D","O'Connell J","Ryan ET","Lieberman TD","DeRuff KC","Slater D","Turbett SE","Lagerborg KA","Farhat M","Chaluvadi S","Chapman SB","Pierce VM","Branda J","Philippakis A","Anahtar MN","Lemieux JE","Smole S","Loreth C","Flowers K","Luban J","LaRocque RC","Rosenberg E","Adams G","Rudy M","Harris JB","Gnirke A","Burns M","Reilly SK","Madoff LC","Krasilnikova LA","Bauer MR","Kemball ME","Fink T","Sabeti PC"],"additional_accession":[]},"is_claimable":false,"name":"Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events.","description":"SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and analyzed 772 complete SARS-CoV-2 genomes from the region, including nearly all confirmed cases within the first week of the epidemic and hundreds of cases from major outbreaks at a conference, a nursing facility, and among homeless shelter guests and staff. The data reveal over 80 introductions into the Boston area, predominantly from elsewhere in the United States and Europe. We studied two superspreading events covered by the data, events that led to very different outcomes because of the timing and populations involved. One produced rapid","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-04-22T03:10:56.55Z","creation":"2026-04-22T03:07:18.71Z"},"accession":"S-EPMC7457619","cross_references":{"pubmed":["32869040"],"doi":["10.1101/2020.08.23.20178236"]}}