{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pierzynowska K"],"funding":["Narodowe Centrum Nauki"],"pagination":["3363-3370"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7461230"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["594(20)"],"pubmed_abstract":["We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that "],"journal":["FEBS letters"],"pubmed_title":["Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19."],"pmcid":["PMC7461230"],"funding_grant_id":["2017/25/B/NZ2/00414"],"pubmed_authors":["Pierzynowska K","Gaffke L","Wegrzyn G"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19.","description":"We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-05-02T22:44:45.946Z","creation":"2025-04-25T18:11:58.731Z"},"accession":"S-EPMC7461230","cross_references":{"pubmed":["32880920"],"doi":["10.1002/1873-3468.13908"]}}