biostudies-literaturePierzynowska KNarodowe Centrum Nauki3363-3370https://www.ebi.ac.uk/biostudies/studies/S-EPMC7461230biostudies-literatureUnknown594(20)We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that FEBS lettersTranscriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19.PMC74612302017/25/B/NZ2/00414Pierzynowska KGaffke LWegrzyn GfalseTranscriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19.We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that 2020-01-01T00:00:00Z2020 Oct2026-05-02T22:44:45.946Z2025-04-25T18:11:58.731ZS-EPMC74612303288092010.1002/1873-3468.13908