{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Serpa GL"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["306-316"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7462344"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(3)"],"pubmed_abstract":["Electronic nicotine delivery system (ENDS) use is outpacing our understanding of its potential harmful effects. Homeostasis of the lung is maintained through proper balance of cell death, efferocytic clearance, and phagocytosis of pathogens. To investigate whether ENDS use has the potential to alter this balance, we developed physiologically relevant ENDS exposure paradigms for lung epithelial cells and primary macrophages. In our studies, cells were exposed directly to aerosol made from carefully controlled components with and without nicotine. We found that ENDS aerosol exposure led to apoptosis, secondary necrosis, and necrosis in lung epithelial cell models. In contrast, macrophages died mostly by apoptosis and inflammatory caspase-mediated cell death when exposed to ENDS aerosol. The "],"journal":["American journal of respiratory cell and molecular biology"],"pubmed_title":["Electronic Nicotine Delivery System Aerosol-induced Cell Death and Dysfunction in Macrophages and Lung Epithelial Cells."],"pmcid":["PMC7462344"],"funding_grant_id":["R01 HL126887","P20 GM103430","T32 ES007272"],"pubmed_authors":["Serpa GL","Crane MJ","Jamieson AM","Lee N","Renton ND"],"additional_accession":[]},"is_claimable":false,"name":"Electronic Nicotine Delivery System Aerosol-induced Cell Death and Dysfunction in Macrophages and Lung Epithelial Cells.","description":"Electronic nicotine delivery system (ENDS) use is outpacing our understanding of its potential harmful effects. Homeostasis of the lung is maintained through proper balance of cell death, efferocytic clearance, and phagocytosis of pathogens. To investigate whether ENDS use has the potential to alter this balance, we developed physiologically relevant ENDS exposure paradigms for lung epithelial cells and primary macrophages. In our studies, cells were exposed directly to aerosol made from carefully controlled components with and without nicotine. We found that ENDS aerosol exposure led to apoptosis, secondary necrosis, and necrosis in lung epithelial cell models. In contrast, macrophages died mostly by apoptosis and inflammatory caspase-mediated cell death when exposed to ENDS aerosol. The ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-07T16:19:20.869Z","creation":"2022-02-11T10:01:51.694Z"},"accession":"S-EPMC7462344","cross_references":{"pubmed":["32469619"],"doi":["10.1165/rcmb.2019-0200OC","10.1165/rcmb.2019-0200oc"]}}