{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mester-Tonczar J"],"funding":["FIBROTARGETs EU project"],"pagination":["E1180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7463784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(8)"],"pubmed_abstract":["Anti-fibrotic therapies are of increasing interest to combat cardiac remodeling and heart failure progression. Recently, anti-fibrotic circular RNAs (circRNAs) have been identified in human and rodent cardiac tissue. In vivo (rodent) experiments proved cardiac anti-fibrotic effects of the natural compounds bufalin and lycorine by downregulating miRNA-671-5p, associated with a theoretic increase in the tissue level of circRNA CDR1as. Accordingly, we hypothesized that both anti-fibrotic drugs may inhibit focal myocardial fibrosis of the remodeled left ventricle (LV) also in a translational large animal model of heart failure (HF). Domestic pigs were repeatedly treated with subcutaneous injections of either bufalin, lycorine, or saline, (n = 5/group) between days 7-21 post acute myocardial in"],"journal":["Biomolecules"],"pubmed_title":["Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine."],"pmcid":["PMC7463784"],"funding_grant_id":["602904"],"pubmed_authors":["Gyongyosi M","Zlabinger K","Traxler D","Winkler J","Einzinger P","Hasimbegovic E","Thum T","Kastner N","Lukovic D","Spannbauer A","Batkai S","Mester-Tonczar J"],"additional_accession":[]},"is_claimable":false,"name":"Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine.","description":"Anti-fibrotic therapies are of increasing interest to combat cardiac remodeling and heart failure progression. Recently, anti-fibrotic circular RNAs (circRNAs) have been identified in human and rodent cardiac tissue. In vivo (rodent) experiments proved cardiac anti-fibrotic effects of the natural compounds bufalin and lycorine by downregulating miRNA-671-5p, associated with a theoretic increase in the tissue level of circRNA CDR1as. Accordingly, we hypothesized that both anti-fibrotic drugs may inhibit focal myocardial fibrosis of the remodeled left ventricle (LV) also in a translational large animal model of heart failure (HF). Domestic pigs were repeatedly treated with subcutaneous injections of either bufalin, lycorine, or saline, (n = 5/group) between days 7-21 post acute myocardial in","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-05-07T15:28:56.418Z","creation":"2020-09-06T07:04:16Z"},"accession":"S-EPMC7463784","cross_references":{"pubmed":["32823854"],"doi":["10.3390/biom10081180"]}}