{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(16)"],"submitter":["Yue GG"],"pubmed_abstract":["Tricin, a flavone isolated from rice bran, has been shown to be chemopreventive in a colorectal cancer (CRC) mouse model. This study aimed to illustrate the inhibitory activities of tricin in colon cancer cells and in a metastatic CRC mouse model. BALB/c mice injected with mouse Colon26-Luc cells into the rectum wall were treated with tricin (37.5 mg/kg) daily for 18 days. Orthotopic colon tumor growth and metastasis to lungs were assessed by in vivo bioluminescence imaging. Results showed that tricin suppressed Colon-Luc cells motility and downregulated phosphorylated Akt, Erk1/2 and NF-κB expressions of human colon cancer HT-29 cells. While tricin treatment suppressed tumor growth and lung metastasis as well as altered the populations of myeloid-derived suppressor cells and regulatory T "],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E3730"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7463810"],"repository":["biostudies-literature"],"pubmed_title":["A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice."],"pmcid":["PMC7463810"],"pubmed_authors":["Shaw PC","Lau CB","Lee JK","Wong EC","Yue GG","Chan YY","Li XX","Gao S","Zheng T","Simmonds MSJ"],"additional_accession":[]},"is_claimable":false,"name":"A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice.","description":"Tricin, a flavone isolated from rice bran, has been shown to be chemopreventive in a colorectal cancer (CRC) mouse model. This study aimed to illustrate the inhibitory activities of tricin in colon cancer cells and in a metastatic CRC mouse model. BALB/c mice injected with mouse Colon26-Luc cells into the rectum wall were treated with tricin (37.5 mg/kg) daily for 18 days. Orthotopic colon tumor growth and metastasis to lungs were assessed by in vivo bioluminescence imaging. Results showed that tricin suppressed Colon-Luc cells motility and downregulated phosphorylated Akt, Erk1/2 and NF-κB expressions of human colon cancer HT-29 cells. While tricin treatment suppressed tumor growth and lung metastasis as well as altered the populations of myeloid-derived suppressor cells and regulatory T ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-18T17:40:43.972Z","creation":"2020-09-06T07:02:38Z"},"accession":"S-EPMC7463810","cross_references":{"pubmed":["32824166"],"doi":["10.3390/molecules25163730"]}}