{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Helderman RFCPA"],"funding":["KWF Kankerbestrijding"],"pagination":["E1775"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7464333"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment with curative intent for peritoneal metastasis of colorectal cancer (CRC). Currently, there is no standardized HIPEC protocol: choice of drug, perfusate temperature, and duration of treatment vary per institute. We investigated the temperature-dependent effectiveness of drugs often used in HIPEC.<h4>Methods</h4>The effect of temperature on drug uptake, DNA damage, apoptosis, cell cycle distribution, and cell growth were assessed using the temperature-dependent IC50 and Thermal Enhancement Ratio (TER) values of the chemotherapeutic drugs cisplatin, oxaliplatin, carboplatin, mitomycin-C (MMC), and 5-fluorouracil (5-FU) on 2D and 3D CRC cell cultures at clinically relevant hyperthermic con"],"journal":["Cells"],"pubmed_title":["The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines."],"pmcid":["PMC7464333"],"funding_grant_id":["UVA grant number 10595"],"pubmed_authors":["Loke DR","Garcia Vallejo JJ","Franken NAP","Verhoeff J","Boon M","Kok HP","Helderman RFCPA","Rodermond HM","Oei AL","van Kesteren S","Crezee J","van Bochove GGW","Tanis PJ"],"additional_accession":[]},"is_claimable":false,"name":"The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines.","description":"Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment with curative intent for peritoneal metastasis of colorectal cancer (CRC). Currently, there is no standardized HIPEC protocol: choice of drug, perfusate temperature, and duration of treatment vary per institute. We investigated the temperature-dependent effectiveness of drugs often used in HIPEC.<h4>Methods</h4>The effect of temperature on drug uptake, DNA damage, apoptosis, cell cycle distribution, and cell growth were assessed using the temperature-dependent IC50 and Thermal Enhancement Ratio (TER) values of the chemotherapeutic drugs cisplatin, oxaliplatin, carboplatin, mitomycin-C (MMC), and 5-fluorouracil (5-FU) on 2D and 3D CRC cell cultures at clinically relevant hyperthermic con","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-07T16:03:52.728Z","creation":"2020-09-10T07:16:11Z"},"accession":"S-EPMC7464333","cross_references":{"pubmed":["32722384"],"doi":["10.3390/cells9081775"]}}