{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su WP"],"funding":["Ministry of Science and Technology, Taiwan","National Health Research Institutes"],"pagination":["E2189"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7464583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(8)"],"pubmed_abstract":["Synthetic Zfra4-10 and WWOX7-21 peptides strongly suppress cancer growth in vivo. Hypothetically, Zfra4-10 binds to the membrane Hyal-2 of spleen Z cells and activates the Hyal-2/WWOX/SMAD4 signaling for cytotoxic Z cell activation to kill cancer cells. Stimulation of membrane WWOX in the signaling complex by a WWOX epitope peptide, WWOX7-21, is likely to activate the signaling. Here, mice receiving Zfra4-10 or WWOX7-21 peptide alone exhibited an increased binding of endogenous tumor suppressor WWOX with ERK, C1qBP, NF-κB, Iba1, p21, CD133, JNK1, COX2, Oct4, and GFAP in the spleen, brain, and/or lung which led to cancer suppression. However, when in combination, Zfra4-10 and WWOX7-21 reduced the binding of WWOX with target proteins and allowed tumor growth in vivo. In addition to Zfra4-10 "],"journal":["Cancers"],"pubmed_title":["Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo."],"pmcid":["PMC7464583"],"funding_grant_id":["106-2320-B-006-061","105–2320-B-006-046","105-2320-B-006-036","105-2320-B-006-046","107-2320-B-006-058-MY3","106–2320-B-006-061","107-2320-B-006-005","106-2320-B-006-017","106–2320-B-006-017","105–2320-B-006-036","NHRI-EX107-10734NI"],"pubmed_authors":["Chang JY","Liu TY","Kuo HL","Chen YA","Lee MH","Huang SS","Lin SR","Ho PC","Subhan D","Wu CY","Lu CY","Chang NS","Sze CI","Su WP","Wang WJ","Chiang MF","Chen YJ","Wen KY"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo.","description":"Synthetic Zfra4-10 and WWOX7-21 peptides strongly suppress cancer growth in vivo. Hypothetically, Zfra4-10 binds to the membrane Hyal-2 of spleen Z cells and activates the Hyal-2/WWOX/SMAD4 signaling for cytotoxic Z cell activation to kill cancer cells. Stimulation of membrane WWOX in the signaling complex by a WWOX epitope peptide, WWOX7-21, is likely to activate the signaling. Here, mice receiving Zfra4-10 or WWOX7-21 peptide alone exhibited an increased binding of endogenous tumor suppressor WWOX with ERK, C1qBP, NF-κB, Iba1, p21, CD133, JNK1, COX2, Oct4, and GFAP in the spleen, brain, and/or lung which led to cancer suppression. However, when in combination, Zfra4-10 and WWOX7-21 reduced the binding of WWOX with target proteins and allowed tumor growth in vivo. In addition to Zfra4-10 ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-04-07T21:58:39.552Z","creation":"2020-09-09T07:09:01Z"},"accession":"S-EPMC7464583","cross_references":{"pubmed":["32764489"],"doi":["10.3390/cancers12082189"]}}