{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin YH"],"funding":["National Institute of Neurological Disorders and Stroke","National Research Council of Science and Technology"],"pagination":["E1787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7465974"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["Theiler's murine encephalomyelitis virus (TMEV) induces immune-mediated inflammatory demyelinating disease in susceptible mice that is similar to human multiple sclerosis (MS). In light of anti-CD20 therapies for MS, the susceptibility of B cells to TMEV infection is particularly important. In our study, direct viral exposure to macrophages and lymphocytes resulted in viral replication and cellular stimulation in the order of DCs, macrophages, B cells, and T cells. Notably, B cells produced viral proteins and expressed elevated levels of CD69, an activation marker. Similarly, the expression of major histocompatibility complex class II and costimulatory molecules in B cells was upregulated. Moreover, TMEV-infected B cells showed elevated levels of antigen-presenting function and antibody pr"],"journal":["Cells"],"pubmed_title":["Infection and Activation of B Cells by Theiler's Murine Encephalomyelitis Virus (TMEV) Leads to Autoantibody Production in an Infectious Model of Multiple Sclerosis."],"pmcid":["PMC7465974"],"funding_grant_id":["RO1 NS28752, RO1 NS33008","CRC-16-01-KRICT, NSN1621350"],"pubmed_authors":["Jin YH","Kim CX","Huang J","Kim BS"],"additional_accession":[]},"is_claimable":false,"name":"Infection and Activation of B Cells by Theiler's Murine Encephalomyelitis Virus (TMEV) Leads to Autoantibody Production in an Infectious Model of Multiple Sclerosis.","description":"Theiler's murine encephalomyelitis virus (TMEV) induces immune-mediated inflammatory demyelinating disease in susceptible mice that is similar to human multiple sclerosis (MS). In light of anti-CD20 therapies for MS, the susceptibility of B cells to TMEV infection is particularly important. In our study, direct viral exposure to macrophages and lymphocytes resulted in viral replication and cellular stimulation in the order of DCs, macrophages, B cells, and T cells. Notably, B cells produced viral proteins and expressed elevated levels of CD69, an activation marker. Similarly, the expression of major histocompatibility complex class II and costimulatory molecules in B cells was upregulated. Moreover, TMEV-infected B cells showed elevated levels of antigen-presenting function and antibody pr","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-05-29T20:43:34.501Z","creation":"2025-05-29T20:43:34.501Z"},"accession":"S-EPMC7465974","cross_references":{"pubmed":["32727036"],"doi":["10.3390/cells9081787"]}}