biostudies-literatureRamirez-Tejero JAConsejería de Economía, Innovación, Ciencia y Empleo, Junta de AndalucíaE2386https://www.ebi.ac.uk/biostudies/studies/S-EPMC7468876biostudies-literatureUnknown12(8)Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of extra virgin olive oil, and particularly of one of its phenolic compounds, hydroxytyrosol (HT), has proven to be protective in terms of redox homeostatic balance and the reduction of inflammation. In this context, using a proteomic approach with nanoscale liquid chromatography coupled to tandem mass spectrometry, the present study analysed: (i) Changes in the proteome of dermal fibroblasts from a patient with FM versus a healthy control, and (ii) the effect of the treatment with a nutritioNutrientsHydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia.PMC7468876BIO-184Ramirez-Tejero JAPeinado MAMartinez-Lara EDel Moral MLSiles EfalseHydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia.Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of extra virgin olive oil, and particularly of one of its phenolic compounds, hydroxytyrosol (HT), has proven to be protective in terms of redox homeostatic balance and the reduction of inflammation. In this context, using a proteomic approach with nanoscale liquid chromatography coupled to tandem mass spectrometry, the present study analysed: (i) Changes in the proteome of dermal fibroblasts from a patient with FM versus a healthy control, and (ii) the effect of the treatment with a nutritio2020-01-01T00:00:00Z2020 Aug2026-04-08T00:14:37.041Z2020-09-09T07:07:24ZS-EPMC74688763278491510.3390/nu12082386