biostudies-literatureHeymans CKinderonderzoekfonds Limburg82https://www.ebi.ac.uk/biostudies/studies/S-EPMC7469100biostudies-literatureUnknown26(1)<h4>Background</h4>Chorioamnionitis, inflammation of the chorion and amnion, which often results from intrauterine infection, is associated with premature birth and contributes to significant neonatal morbidity and mortality, including necrotizing enterocolitis (NEC). Recently, we have shown that chronic chorioamnionitis is associated with significant structural enteric nervous system (ENS) abnormalities that may predispose to later NEC development. Understanding time point specific effects of an intra-amniotic (IA) infection on the ENS is important for further understanding the pathophysiological processes and for finding a window for optimal therapeutic strategies for an individual patient. The aim of this study was therefore to gain insight in the longitudinal effects of intrauterine LPMolecular medicine (Cambridge, Mass.)Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus.PMC7469100Not applicableLenaerts KKessels LCGABoesmans Wde Lange IHKramer BWHeymans CSaito MKemp MWvan Gemert WGMelotte VHadfoune MRademakers GJobe AHWolfs TGAMfalseChorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus.<h4>Background</h4>Chorioamnionitis, inflammation of the chorion and amnion, which often results from intrauterine infection, is associated with premature birth and contributes to significant neonatal morbidity and mortality, including necrotizing enterocolitis (NEC). Recently, we have shown that chronic chorioamnionitis is associated with significant structural enteric nervous system (ENS) abnormalities that may predispose to later NEC development. Understanding time point specific effects of an intra-amniotic (IA) infection on the ENS is important for further understanding the pathophysiological processes and for finding a window for optimal therapeutic strategies for an individual patient. The aim of this study was therefore to gain insight in the longitudinal effects of intrauterine LP2020-01-01T00:00:00Z2020 Sep2025-04-18T17:43:23.377Z2020-09-06T07:03:50ZS-EPMC74691003288319810.1186/s10020-020-00206-x