{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Jakopovic B"],"pubmed_abstract":["Colorectal cancer (CRC) is the third most frequent cancer type in both males and females, with about 35% of patients being diagnosed in stage IV metastatic disease. Despite advancements in treatment, life expectancy in patients with metastatic disease is still not satisfying. Due to frequent drug resistance during conventional and targeted cancer treatments, the development and testing of multi-target therapies is an important research field. Medicinal mushrooms specific isolated compounds as well as complex extract mixtures have been studied in depth, and many mushroom species have been proven to be non-toxic multi-target inhibitors of specific oncogenic pathways, as well as potent immunomodulators. In this study, we have performed a tandem mass tags qualitative and quantitative proteomic"],"journal":["Frontiers in pharmacology"],"pagination":["1202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7472604"],"repository":["biostudies-literature"],"pubmed_title":["Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis."],"pmcid":["PMC7472604"],"pubmed_authors":["Jakopovich I","Jakopovic B","Orsolic N","Kraljevic Pavelic S","Horvatic A","Gelemanovic A","Klobucar M","Grbcic P"],"additional_accession":[]},"is_claimable":false,"name":"Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis.","description":"Colorectal cancer (CRC) is the third most frequent cancer type in both males and females, with about 35% of patients being diagnosed in stage IV metastatic disease. Despite advancements in treatment, life expectancy in patients with metastatic disease is still not satisfying. Due to frequent drug resistance during conventional and targeted cancer treatments, the development and testing of multi-target therapies is an important research field. Medicinal mushrooms specific isolated compounds as well as complex extract mixtures have been studied in depth, and many mushroom species have been proven to be non-toxic multi-target inhibitors of specific oncogenic pathways, as well as potent immunomodulators. In this study, we have performed a tandem mass tags qualitative and quantitative proteomic","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-29T08:20:09.986Z","creation":"2025-05-31T23:51:56.465Z"},"accession":"S-EPMC7472604","cross_references":{"pubmed":["32973493"],"doi":["10.3389/fphar.2020.01202"]}}