{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["NIDCR NIH HHS","NCCIH NIH HHS"],"pagination":["1638-47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7473329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(10)"],"pubmed_abstract":["Modification of surfaces mimicking unique chemical and physical features of mineralized tissues is of major interest for obtaining biomaterials for replacing and regenerating biological tissues. Here, human salivary statherin-inspired genetically engineered recombinamers (ELRs, HSS) on biomedical surfaces regulates mineralization to form an amorphous-calcium-phosphate (ACP) layer that reproduces the original substrate nanotopography. The HSS-ELRs carry a statherin-derived peptide with high affinity to tooth enamel. They are tethered to nanorough surfaces and mineralized using an enzyme-directed process. A homogeneous layer of ACP-minerals forms on HSS-coated surfaces retaining the original nanotopography of the substrate. In contrast, biomineralization of control surfaces results in uncont"],"journal":["Advanced healthcare materials"],"pubmed_title":["Hybrid nanotopographical surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers."],"pmcid":["PMC7473329"],"funding_grant_id":["F05 AT002009","R90 DE023058"],"pubmed_authors":["Holmberg KV","Li Y","Rodriguez-Cabello JC","Chen X","Ribeiro AJ","Aparicio C","Jensen ED"],"additional_accession":[]},"is_claimable":false,"name":"Hybrid nanotopographical surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers.","description":"Modification of surfaces mimicking unique chemical and physical features of mineralized tissues is of major interest for obtaining biomaterials for replacing and regenerating biological tissues. Here, human salivary statherin-inspired genetically engineered recombinamers (ELRs, HSS) on biomedical surfaces regulates mineralization to form an amorphous-calcium-phosphate (ACP) layer that reproduces the original substrate nanotopography. The HSS-ELRs carry a statherin-derived peptide with high affinity to tooth enamel. They are tethered to nanorough surfaces and mineralized using an enzyme-directed process. A homogeneous layer of ACP-minerals forms on HSS-coated surfaces retaining the original nanotopography of the substrate. In contrast, biomineralization of control surfaces results in uncont","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-26T01:37:00.667Z","creation":"2025-04-26T01:37:00.667Z"},"accession":"S-EPMC7473329","cross_references":{"pubmed":["24700504"],"doi":["10.1002/adhm.201400015"]}}