{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Herrmann M"],"funding":["Deutsches Zentrum für Infektionsforschung","Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["Coronavirus disease 2019 (COVID-19) which is caused by the novel SARS-CoV-2 virus is a severe flu-like illness which is associated with hyperinflammation and immune dysfunction. The virus induces a strong T and B cell response but little is known about the immune pathology of this viral infection. Acute <i>Plasmodium falciparum</i> malaria also causes acute clinical illness and is characterized by hyperinflammation due to the strong production of pro-inflammatory cytokines and a massive activation of T cells. In malaria, T cells express a variety of co-inhibitory receptors which might be a consequence of their activation but also might limit their overwhelming function. Thus, T cells are implicated in protection as well as in pathology. The outcome of malaria is thought to be a consequence"],"journal":["Frontiers in immunology"],"pagination":["1870"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7479337"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute <i>Plasmodium falciparum</i> Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease."],"pmcid":["PMC7479337"],"pubmed_authors":["Herrmann M","Woost R","Wildner NH","Jacobs T","Schulze Zur Wiesch J","Schulte S","Lohse AW","Wittner M","Ramharter M","Brehm TT"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute <i>Plasmodium falciparum</i> Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease.","description":"Coronavirus disease 2019 (COVID-19) which is caused by the novel SARS-CoV-2 virus is a severe flu-like illness which is associated with hyperinflammation and immune dysfunction. The virus induces a strong T and B cell response but little is known about the immune pathology of this viral infection. Acute <i>Plasmodium falciparum</i> malaria also causes acute clinical illness and is characterized by hyperinflammation due to the strong production of pro-inflammatory cytokines and a massive activation of T cells. In malaria, T cells express a variety of co-inhibitory receptors which might be a consequence of their activation but also might limit their overwhelming function. Thus, T cells are implicated in protection as well as in pathology. The outcome of malaria is thought to be a consequence","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-07-16T04:38:32.785Z","creation":"2026-07-09T10:36:35.616Z"},"accession":"S-EPMC7479337","cross_references":{"pubmed":["32983106"],"doi":["10.3389/fimmu.2020.01870"]}}