biostudies-literatureUnknown11Herrmann MDeutsches Zentrum für InfektionsforschungDeutsche ForschungsgemeinschaftCoronavirus disease 2019 (COVID-19) which is caused by the novel SARS-CoV-2 virus is a severe flu-like illness which is associated with hyperinflammation and immune dysfunction. The virus induces a strong T and B cell response but little is known about the immune pathology of this viral infection. Acute <i>Plasmodium falciparum</i> malaria also causes acute clinical illness and is characterized by hyperinflammation due to the strong production of pro-inflammatory cytokines and a massive activation of T cells. In malaria, T cells express a variety of co-inhibitory receptors which might be a consequence of their activation but also might limit their overwhelming function. Thus, T cells are implicated in protection as well as in pathology. The outcome of malaria is thought to be a consequenceFrontiers in immunology1870https://www.ebi.ac.uk/biostudies/studies/S-EPMC7479337biostudies-literatureAnalysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute <i>Plasmodium falciparum</i> Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease.PMC7479337Herrmann MWoost RWildner NHJacobs TSchulze Zur Wiesch JSchulte SLohse AWWittner MRamharter MBrehm TTfalseAnalysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute <i>Plasmodium falciparum</i> Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease.Coronavirus disease 2019 (COVID-19) which is caused by the novel SARS-CoV-2 virus is a severe flu-like illness which is associated with hyperinflammation and immune dysfunction. The virus induces a strong T and B cell response but little is known about the immune pathology of this viral infection. Acute <i>Plasmodium falciparum</i> malaria also causes acute clinical illness and is characterized by hyperinflammation due to the strong production of pro-inflammatory cytokines and a massive activation of T cells. In malaria, T cells express a variety of co-inhibitory receptors which might be a consequence of their activation but also might limit their overwhelming function. Thus, T cells are implicated in protection as well as in pathology. The outcome of malaria is thought to be a consequence2020-01-01T00:00:00Z20202026-07-16T04:38:32.785Z2026-07-09T10:36:35.616ZS-EPMC74793373298310610.3389/fimmu.2020.01870