{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bornhauser B"],"funding":["Swiss National Science Foundation"],"pagination":["4052-4064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7479947"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(17)"],"pubmed_abstract":["Most relapses of acute lymphoblastic leukemia (ALL) occur in patients with a medium risk (MR) for relapse on the Associazione Italiana di Ematologia e Oncologia Pediatrica and Berlin-Frankfurt-Münster (AIEOP-BFM) ALL protocol, based on persistence of minimal residual disease (MRD). New insights into biological features that are associated with MRD are needed. Here, we identify the glycosylphosphatidylinositol-anchored cell surface protein vanin-2 (VNN2; GPI-80) by charting the cell surface proteome of MRD very high-risk (HR) B-cell precursor (BCP) ALL using a chemoproteomics strategy. The correlation between VNN2 transcript and surface protein expression enabled a retrospective analysis (ALL-BFM 2000; N = 770 cases) using quantitative polymerase chain reaction to confirm the association of"],"journal":["Blood advances"],"pubmed_title":["The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL."],"pmcid":["PMC7479947"],"funding_grant_id":["182269","156407","310030"],"pubmed_authors":["Wollscheid B","Zimmermann M","Temperli M","Rodriguez Martinez V","Scheidegger N","Rinaldi A","Hauri-Hohl M","Mirkowska P","Bruggemann M","Gaipa G","Basso G","Ngo Q","Vendramini E","Schrappe M","Dworzak M","Attarbaschi A","Panzer-Grumayer R","Marovca B","Eckert C","Moller C","Barz MJ","Yaspo ML","Schumich A","Bourquin JP","Mejstrikova E","Te Kronnie G","Buldini B","Scarparo P","Niggli F","Warnatz HJ","Schutte M","Skroblyn TL","Bornhauser B","Risch T","Ritgen M","Stanulla M","Hofmann A","Maglia O","Cario G"],"additional_accession":[]},"is_claimable":false,"name":"The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL.","description":"Most relapses of acute lymphoblastic leukemia (ALL) occur in patients with a medium risk (MR) for relapse on the Associazione Italiana di Ematologia e Oncologia Pediatrica and Berlin-Frankfurt-Münster (AIEOP-BFM) ALL protocol, based on persistence of minimal residual disease (MRD). New insights into biological features that are associated with MRD are needed. Here, we identify the glycosylphosphatidylinositol-anchored cell surface protein vanin-2 (VNN2; GPI-80) by charting the cell surface proteome of MRD very high-risk (HR) B-cell precursor (BCP) ALL using a chemoproteomics strategy. The correlation between VNN2 transcript and surface protein expression enabled a retrospective analysis (ALL-BFM 2000; N = 770 cases) using quantitative polymerase chain reaction to confirm the association of","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-04-15T09:03:33.118Z","creation":"2020-09-12T07:08:46Z"},"accession":"S-EPMC7479947","cross_references":{"pubmed":["32853382"],"doi":["10.1182/bloodadvances.2019000938"]}}