biostudies-literatureStevenson NJAustrian Science Fund FWFSuomalainen TiedeakatemiaEuropean Commission1564-1573https://www.ebi.ac.uk/biostudies/studies/S-EPMC7480927biostudies-literatureUnknown7(9)<h4>Objectives</h4>To determine the accuracy of, and agreement among, EEG and aEEG readers' estimation of maturity and a novel computational measure of functional brain age (FBA) in preterm infants.<h4>Methods</h4>Seven experts estimated the postmenstrual ages (PMA) in a cohort of recordings from preterm infants using cloud-based review software. The FBA was calculated using a machine learning-based algorithm. Error analysis was used to determine the accuracy of PMA assessments and intraclass correlation (ICC) was used to assess agreement between experts.<h4>Results</h4>EEG recordings from a PMA range 25 to 38 weeks were successfully interpreted. In 179 recordings from 62 infants interpreted by all human readers, there was moderate agreement between experts (aEEG ICC = 0.724; 95%CI:0.658-0Annals of clinical and translational neurologyReliability and accuracy of EEG interpretation for estimating age in preterm infants.PMC7480927KLI2373104450H2020‐MCSA‐IF‐656131313242288220Clancy RRKaminska ATataranno MLStevenson NJGriesmaier ERoberts JAKlebermass-Schrehof KPavlidis EVanhatalo SfalseReliability and accuracy of EEG interpretation for estimating age in preterm infants.<h4>Objectives</h4>To determine the accuracy of, and agreement among, EEG and aEEG readers' estimation of maturity and a novel computational measure of functional brain age (FBA) in preterm infants.<h4>Methods</h4>Seven experts estimated the postmenstrual ages (PMA) in a cohort of recordings from preterm infants using cloud-based review software. The FBA was calculated using a machine learning-based algorithm. Error analysis was used to determine the accuracy of PMA assessments and intraclass correlation (ICC) was used to assess agreement between experts.<h4>Results</h4>EEG recordings from a PMA range 25 to 38 weeks were successfully interpreted. In 179 recordings from 62 infants interpreted by all human readers, there was moderate agreement between experts (aEEG ICC = 0.724; 95%CI:0.658-02020-01-01T00:00:00Z2020 Sep2025-06-01T00:14:45.463Z2025-06-01T00:14:45.463ZS-EPMC74809273276764510.1002/acn3.51132