{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(36)"],"submitter":["Gara SK"],"pubmed_abstract":["Recent evidence has implicated <i>APOBEC3B</i> (Apolipoprotein B mRNA editing enzyme catalytic subunit 3B) as a source of mutations in breast, bladder, cervical, lung, head, and neck cancers. However, the role of APOBEC3B in adrenocortical carcinoma (ACC) and the mechanisms through which its expression is regulated in cancer are not fully understood. Here, we report that APOBEC3B is overexpressed in ACC and it regulates cell proliferation by inducing S phase arrest. We show high <i>APOBEC3B</i> expression is associated with a higher copy number gain/loss at chromosome 4 and 8 and <i>TP53</i> mutation rate in ACC. GATA3 was identified as a positive regulator of <i>APOBEC3B</i> expression and directly binds the APOBEC3B promoter region. Both GATA3 and APOBEC3B expression levels were associat"],"journal":["Oncotarget"],"pagination":["3354-3370"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7486697"],"repository":["biostudies-literature"],"pubmed_title":["GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3."],"pmcid":["PMC7486697"],"pubmed_authors":["Liu Y","Lack J","Kebebew E","Patel DT","Gara SK","Gaskins K","Tyagi MV"],"additional_accession":[]},"is_claimable":false,"name":"GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.","description":"Recent evidence has implicated <i>APOBEC3B</i> (Apolipoprotein B mRNA editing enzyme catalytic subunit 3B) as a source of mutations in breast, bladder, cervical, lung, head, and neck cancers. However, the role of APOBEC3B in adrenocortical carcinoma (ACC) and the mechanisms through which its expression is regulated in cancer are not fully understood. Here, we report that APOBEC3B is overexpressed in ACC and it regulates cell proliferation by inducing S phase arrest. We show high <i>APOBEC3B</i> expression is associated with a higher copy number gain/loss at chromosome 4 and 8 and <i>TP53</i> mutation rate in ACC. GATA3 was identified as a positive regulator of <i>APOBEC3B</i> expression and directly binds the APOBEC3B promoter region. Both GATA3 and APOBEC3B expression levels were associat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-03T05:08:32.636Z","creation":"2020-09-17T07:03:34Z"},"accession":"S-EPMC7486697","cross_references":{"pubmed":["32934779"],"doi":["10.18632/oncotarget.27703"]}}