{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Song E"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NIMH NIH HHS","NINDS NIH HHS","NCI NIH HHS","NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["One third of COVID-19 patients develop significant neurological symptoms, yet SARS-CoV-2 is rarely detected in central nervous system (CNS) tissue, suggesting a potential role for parainfectious processes, including neuroimmune responses. We therefore examined immune parameters in cerebrospinal fluid (CSF) and blood samples from a cohort of patients with COVID-19 and significant neurological complications. We found divergent immunological responses in the CNS compartment, including increased levels of IL-12 and IL-12-associated innate and adaptive immune cell activation. Moreover, we found increased proportions of B cells in the CSF relative to the periphery and evidence of clonal expansion of CSF B cells, suggesting a divergent intrathecal humoral response to SARS-CoV-2. Indeed, all COVID"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2020.09.11.293464"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7491516"],"repository":["biostudies-literature"],"pubmed_title":["Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement."],"pmcid":["PMC7491516"],"funding_grant_id":["R01 MH122471","F30 CA239444","F30 CA250249","T32 GM136651","U19 AI089992","K23 MH118999","UL1 TR001863","S10 OD021801","R01 AI157488","K08 NS096117","R21 MH118109","R01 AI104739"],"pubmed_authors":["Gallego JA","Bartley CM","Alvarenga BD","Mao T","Oh J","Pleasure SJ","Zamecnik CR","Chow RD","Jiang R","Phinney BS","Rahman NT","Alexander J","Dai Y","Lucas C","Lencz T","Ngo TT","Iwasaki A","Vogels CBF","Grubaugh ND","Walsh H","Casanovas-Massana A","Kleinstein SH","Dandekar R","Goldman-Israelow B","Ko AI","Ring A","Loudermilk RP","Huynh T","DeRisi JL","Farhadian SF","Chiarella J","Wilson MR","McAlpine L","Hawes IA","Song E","Klein J","Spudich S","Geng B","Salemi M","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement.","description":"One third of COVID-19 patients develop significant neurological symptoms, yet SARS-CoV-2 is rarely detected in central nervous system (CNS) tissue, suggesting a potential role for parainfectious processes, including neuroimmune responses. We therefore examined immune parameters in cerebrospinal fluid (CSF) and blood samples from a cohort of patients with COVID-19 and significant neurological complications. We found divergent immunological responses in the CNS compartment, including increased levels of IL-12 and IL-12-associated innate and adaptive immune cell activation. Moreover, we found increased proportions of B cells in the CSF relative to the periphery and evidence of clonal expansion of CSF B cells, suggesting a divergent intrathecal humoral response to SARS-CoV-2. Indeed, all COVID","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-05-03T03:25:03.47Z","creation":"2020-09-20T07:02:21Z"},"accession":"S-EPMC7491516","cross_references":{"pubmed":["32935102"],"doi":["10.1101/2020.09.11.293464"]}}