{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Levin G"],"funding":["Advanced Ortho-Molecular Research","Lotte and John Hecht Memorial Foundation","South Eastern Academic Medical Association"],"pubmed_abstract":["<h4>Introduction</h4>Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo whole blood stimulation with lipopolysaccharide (LPS) has been proposed as a possible method to quantify immunological function. We hypothesized that in a cohort of critically ill patients, those with a lower post-stimulation TNF-α level would have increased rates of nosocomial infections (NIs) and worse clinical outcomes.<h4>Methods</h4>A secondary analysis of a phase 2 randomized, multi-centre, double-blinded placebo-controlled trial. As there was no difference between treatment and control arms in outcomes and NI rate, all the patients were analyzed as one cohort."],"journal":["Intensive care medicine experimental"],"pagination":["55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7494693"],"repository":["biostudies-literature"],"pubmed_title":["The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients."],"pmcid":["PMC7494693"],"pubmed_authors":["Muscedere J","Day A","Hunt M","O'Callaghan N","Boyd JG","Levin G","Sibley S","Maslove DM","Norman P"],"additional_accession":[]},"is_claimable":false,"name":"The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients.","description":"<h4>Introduction</h4>Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo whole blood stimulation with lipopolysaccharide (LPS) has been proposed as a possible method to quantify immunological function. We hypothesized that in a cohort of critically ill patients, those with a lower post-stimulation TNF-α level would have increased rates of nosocomial infections (NIs) and worse clinical outcomes.<h4>Methods</h4>A secondary analysis of a phase 2 randomized, multi-centre, double-blinded placebo-controlled trial. As there was no difference between treatment and control arms in outcomes and NI rate, all the patients were analyzed as one cohort.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-04T03:58:08.567Z","creation":"2020-10-08T07:26:29Z"},"accession":"S-EPMC7494693","cross_references":{"pubmed":["32936371"],"doi":["10.1186/s40635-020-00344-w"]}}