{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Piesche M"],"funding":["Aarhus Universitets Forskningsfond","Deutsche Forschungsgemeinschaft","Else Kröner-Fresenius-Stiftung"],"pubmed_abstract":["Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. These highly electrophilic fatty acids can undergo Michael addition reaction with cysteine residues, leading to post-translational modifications (PTM) of selected regulatory proteins. Such modifications are capable of changing target protein function during cell signaling or in biosynthetic pathways. NFA target proteins include the peroxisome proliferator-activated receptor <i>γ</i> (PPAR-<i>γ</i>), the pro-inflammatory and tumorigenic nuclear factor-κB (NF-κB) signaling pathway, the pro-inflammatory 5-lipoxygenases (5-LO) biosynthesis pathway as well as soluble epoxide h"],"journal":["Frontiers in pharmacology"],"pagination":["1297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7495092"],"repository":["biostudies-literature"],"pubmed_title":["The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer."],"pmcid":["PMC7495092"],"pubmed_authors":["Matrone C","Hellmuth N","Maucher IV","Heinicke U","Awad O","Zacharowski KD","Comerma Steffensen SG","Kuhn B","Piesche M","Brat C","Maier TJ","Steinhilber D","Roos J","Fettel J","Manolikakes G"],"additional_accession":[]},"is_claimable":false,"name":"The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.","description":"Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. These highly electrophilic fatty acids can undergo Michael addition reaction with cysteine residues, leading to post-translational modifications (PTM) of selected regulatory proteins. Such modifications are capable of changing target protein function during cell signaling or in biosynthetic pathways. NFA target proteins include the peroxisome proliferator-activated receptor <i>γ</i> (PPAR-<i>γ</i>), the pro-inflammatory and tumorigenic nuclear factor-κB (NF-κB) signaling pathway, the pro-inflammatory 5-lipoxygenases (5-LO) biosynthesis pathway as well as soluble epoxide h","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-29T19:02:36.537Z","creation":"2020-11-19T16:58:17Z"},"accession":"S-EPMC7495092","cross_references":{"pubmed":["33013366"],"doi":["10.3389/fphar.2020.01297"]}}