biostudies-literatureUnknown11Piesche MAarhus Universitets ForskningsfondDeutsche ForschungsgemeinschaftElse Kröner-Fresenius-StiftungNitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. These highly electrophilic fatty acids can undergo Michael addition reaction with cysteine residues, leading to post-translational modifications (PTM) of selected regulatory proteins. Such modifications are capable of changing target protein function during cell signaling or in biosynthetic pathways. NFA target proteins include the peroxisome proliferator-activated receptor <i>γ</i> (PPAR-<i>γ</i>), the pro-inflammatory and tumorigenic nuclear factor-κB (NF-κB) signaling pathway, the pro-inflammatory 5-lipoxygenases (5-LO) biosynthesis pathway as well as soluble epoxide hFrontiers in pharmacology1297https://www.ebi.ac.uk/biostudies/studies/S-EPMC7495092biostudies-literatureThe Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.PMC7495092Matrone CHellmuth NMaucher IVHeinicke UAwad OZacharowski KDComerma Steffensen SGKuhn BPiesche MBrat CMaier TJSteinhilber DRoos JFettel JManolikakes GfalseThe Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. These highly electrophilic fatty acids can undergo Michael addition reaction with cysteine residues, leading to post-translational modifications (PTM) of selected regulatory proteins. Such modifications are capable of changing target protein function during cell signaling or in biosynthetic pathways. NFA target proteins include the peroxisome proliferator-activated receptor <i>γ</i> (PPAR-<i>γ</i>), the pro-inflammatory and tumorigenic nuclear factor-κB (NF-κB) signaling pathway, the pro-inflammatory 5-lipoxygenases (5-LO) biosynthesis pathway as well as soluble epoxide h2020-01-01T00:00:00Z20202025-05-29T19:02:36.537Z2020-11-19T16:58:17ZS-EPMC74950923301336610.3389/fphar.2020.01297