{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Billing AM"],"funding":["European Research Council","FP7 Nanosciences, Nanotechnologies, Materials and new Production Technologies","H2020 Leadership in Enabling and Industrial Technologies","Seventh Framework Programme","Danish Centre for Nanosafety 2"],"pagination":["4096-4110"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7498156"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(4)"],"pubmed_abstract":["Despite broad application of magnetic nanoparticles in biomedicine and electronics, only a few <i>in vivo</i> studies on biocompatibility are available. In this study, toxicity of magnetic metal oxide nanoparticles on the respiratory system was examined <i>in vivo</i> by single intratracheal instillation in mice. Bronchoalveolar lavage fluid (BALF) samples were collected for proteome analyses by LC-MS/MS, testing Fe<sub>3</sub>O<sub>4</sub> nanoparticles doped with increasing amounts of cobalt (Fe<sub>3</sub>O<sub>4</sub>, CoFe<sub>2</sub>O<sub>4</sub> with an iron to cobalt ratio 5:1, 3:1, 1:3, Co<sub>3</sub>O<sub>4</sub>) at two doses (54 μg, 162 μg per animal) and two time points (day 1 and 3 days postinstillation). In discovery phase, in-depth proteome profiling of a few representative"],"journal":["ACS nano"],"pubmed_title":["Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles."],"pmcid":["PMC7498156"],"funding_grant_id":["720952","320451","646603","310451"],"pubmed_authors":["Tang SVY","Wallin H","Vogel U","Chetwynd AJ","Berthing T","Billing AM","Knudsen KB","Kjeldsen F","Ellis LA","Lynch I"],"additional_accession":[]},"is_claimable":false,"name":"Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles.","description":"Despite broad application of magnetic nanoparticles in biomedicine and electronics, only a few <i>in vivo</i> studies on biocompatibility are available. In this study, toxicity of magnetic metal oxide nanoparticles on the respiratory system was examined <i>in vivo</i> by single intratracheal instillation in mice. Bronchoalveolar lavage fluid (BALF) samples were collected for proteome analyses by LC-MS/MS, testing Fe<sub>3</sub>O<sub>4</sub> nanoparticles doped with increasing amounts of cobalt (Fe<sub>3</sub>O<sub>4</sub>, CoFe<sub>2</sub>O<sub>4</sub> with an iron to cobalt ratio 5:1, 3:1, 1:3, Co<sub>3</sub>O<sub>4</sub>) at two doses (54 μg, 162 μg per animal) and two time points (day 1 and 3 days postinstillation). In discovery phase, in-depth proteome profiling of a few representative","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-05-03T04:50:53.211Z","creation":"2020-10-08T07:03:57Z"},"accession":"S-EPMC7498156","cross_references":{"pubmed":["32167280"],"doi":["10.1021/acsnano.9b08818"]}}