{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Hotter G"],"pubmed_abstract":["Macrophages show remarkable phenotypic plasticity in response to environmental signals. Although it is generally less considered, cytoskeletal changes in macrophages influence their phenotype, including phagocytosis and secretion of soluble cytokines. Influenza virus NS1A-binding protein (Ivns1abp) belongs to the Kelch family of proteins that play a central role in actin cytoskeleton dynamics by directly associating with F-actin and by protecting against actin derangement. Due to its role in cytoskeleton preservation, the Ivns1abp gene might be a critical regulator of the macrophage phenotype and function under inflammatory conditions. In this study, we determine that the modulation of the Ivns1abp gene in macrophages could modify resistance to macrophages against inflammation and maintain"],"journal":["Scientific reports"],"pagination":["15302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7498593"],"repository":["biostudies-literature"],"pubmed_title":["The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation."],"pmcid":["PMC7498593"],"pubmed_authors":["Sola A","Perez-Calvo JI","Cruzado JM","Hotter G","Brune B","Carbonell T","Mastora C","Jung M","Guiteras R","Josa C"],"additional_accession":[]},"is_claimable":false,"name":"The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation.","description":"Macrophages show remarkable phenotypic plasticity in response to environmental signals. Although it is generally less considered, cytoskeletal changes in macrophages influence their phenotype, including phagocytosis and secretion of soluble cytokines. Influenza virus NS1A-binding protein (Ivns1abp) belongs to the Kelch family of proteins that play a central role in actin cytoskeleton dynamics by directly associating with F-actin and by protecting against actin derangement. Due to its role in cytoskeleton preservation, the Ivns1abp gene might be a critical regulator of the macrophage phenotype and function under inflammatory conditions. In this study, we determine that the modulation of the Ivns1abp gene in macrophages could modify resistance to macrophages against inflammation and maintain","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2025-04-22T14:19:03.208Z","creation":"2020-09-21T07:01:43Z"},"accession":"S-EPMC7498593","cross_references":{"pubmed":["32943673"],"doi":["10.1038/s41598-020-72342-7"]}}