{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rushton L"],"funding":["Medical Research Council"],"pagination":["e01808-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7499027"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(19)"],"pubmed_abstract":["<i>Burkholderia cepacia</i> complex (Bcc) bacteria are intrinsically antimicrobial-resistant opportunistic pathogens and key risk species in the contamination of nonfood industrial products. New agents and formulations to prevent growth of <i>Burkholderia</i> in home care (cleaning agents) and personal-care (cosmetics and toiletries) products are required. We characterized how ethylzingerone [4-(3-ethoxy-4-hydroxyphenyl) butan-2-one] (HEPB) acts as a preservative with activity against <i>Burkholderia</i> species encountered in industry. <i>Burkholderia</i> (<i>n</i> = 58) and non-<i>Burkholderia</i> (<i>n</i> = 7) bacteria were screened for susceptibility to HEPB, and its mode of action and resistance were determined for a model <i>Burkholderia vietnamiensis</i> strain using transposon mut"],"journal":["Applied and environmental microbiology"],"pubmed_title":["Mapping the Efficacy and Mode of Action of Ethylzingerone [4-(3-Ethoxy-4-Hydroxyphenyl) Butan-2-One] as an Active Agent against &lt;i&gt;Burkholderia&lt;/i&gt; Bacteria."],"pmcid":["PMC7499027"],"funding_grant_id":["MR/L015080/1"],"pubmed_authors":["Menard-Szczebara F","Rushton L","Khodr A","Cupferman S","Maillard JY","Mahenthiralingam E"],"additional_accession":[]},"is_claimable":false,"name":"Mapping the Efficacy and Mode of Action of Ethylzingerone [4-(3-Ethoxy-4-Hydroxyphenyl) Butan-2-One] as an Active Agent against &lt;i&gt;Burkholderia&lt;/i&gt; Bacteria.","description":"<i>Burkholderia cepacia</i> complex (Bcc) bacteria are intrinsically antimicrobial-resistant opportunistic pathogens and key risk species in the contamination of nonfood industrial products. New agents and formulations to prevent growth of <i>Burkholderia</i> in home care (cleaning agents) and personal-care (cosmetics and toiletries) products are required. We characterized how ethylzingerone [4-(3-ethoxy-4-hydroxyphenyl) butan-2-one] (HEPB) acts as a preservative with activity against <i>Burkholderia</i> species encountered in industry. <i>Burkholderia</i> (<i>n</i> = 58) and non-<i>Burkholderia</i> (<i>n</i> = 7) bacteria were screened for susceptibility to HEPB, and its mode of action and resistance were determined for a model <i>Burkholderia vietnamiensis</i> strain using transposon mut","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-07T22:04:35.406Z","creation":"2020-10-08T07:18:18Z"},"accession":"S-EPMC7499027","cross_references":{"pubmed":["32737133"],"doi":["10.1128/AEM.01808-20"]}}