biostudies-literatureRushton LMedical Research Councile01808-20https://www.ebi.ac.uk/biostudies/studies/S-EPMC7499027biostudies-literatureUnknown86(19)<i>Burkholderia cepacia</i> complex (Bcc) bacteria are intrinsically antimicrobial-resistant opportunistic pathogens and key risk species in the contamination of nonfood industrial products. New agents and formulations to prevent growth of <i>Burkholderia</i> in home care (cleaning agents) and personal-care (cosmetics and toiletries) products are required. We characterized how ethylzingerone [4-(3-ethoxy-4-hydroxyphenyl) butan-2-one] (HEPB) acts as a preservative with activity against <i>Burkholderia</i> species encountered in industry. <i>Burkholderia</i> (<i>n</i> = 58) and non-<i>Burkholderia</i> (<i>n</i> = 7) bacteria were screened for susceptibility to HEPB, and its mode of action and resistance were determined for a model <i>Burkholderia vietnamiensis</i> strain using transposon mutApplied and environmental microbiologyMapping the Efficacy and Mode of Action of Ethylzingerone [4-(3-Ethoxy-4-Hydroxyphenyl) Butan-2-One] as an Active Agent against <i>Burkholderia</i> Bacteria.PMC7499027MR/L015080/1Menard-Szczebara FRushton LKhodr ACupferman SMaillard JYMahenthiralingam EfalseMapping the Efficacy and Mode of Action of Ethylzingerone [4-(3-Ethoxy-4-Hydroxyphenyl) Butan-2-One] as an Active Agent against <i>Burkholderia</i> Bacteria.<i>Burkholderia cepacia</i> complex (Bcc) bacteria are intrinsically antimicrobial-resistant opportunistic pathogens and key risk species in the contamination of nonfood industrial products. New agents and formulations to prevent growth of <i>Burkholderia</i> in home care (cleaning agents) and personal-care (cosmetics and toiletries) products are required. We characterized how ethylzingerone [4-(3-ethoxy-4-hydroxyphenyl) butan-2-one] (HEPB) acts as a preservative with activity against <i>Burkholderia</i> species encountered in industry. <i>Burkholderia</i> (<i>n</i> = 58) and non-<i>Burkholderia</i> (<i>n</i> = 7) bacteria were screened for susceptibility to HEPB, and its mode of action and resistance were determined for a model <i>Burkholderia vietnamiensis</i> strain using transposon mut2020-01-01T00:00:00Z2020 Sep2026-05-07T22:04:35.406Z2020-10-08T07:18:18ZS-EPMC74990273273713310.1128/AEM.01808-20