biostudies-literatureUnknown10(1)Sharma MA significant proportion of patients with non-alcoholic fatty liver disease (NAFLD) in Asian sub-continent are non-overweight and may have different underlying risk factors, lifestyles and metabolic profiles. Seven hundred fifty patients of NAFLD with raised alanine-amino-transferase (ALT) were divided into non-overweight and obese group based on their body mass index (BMI). Detailed dietary and lifestyle history were obtained through questionnaires and a detailed assessment of metabolic profile and liver stiffness was done. Normal BMI (<?23 kg/m2) was found in 6.6% patients, of which 69.5% had raised ALT. Though the intake of dietary fat and exercise pattern were not different amongst these groups, yet the amount of aerated drinks was higher in obese subjects (12?±?17 vs. 7?±?7.5 p?=?0.005). Serum low-density lipoprotein (111?±?25.6 vs. 127.7?±?32.7 p?=?0.04) and insulin resistance based on HOMA-IR?>?2 were significantly higher in obese group (4.1?±?0.36 vs. 2.0?±?0.15 p?=?0.001). Insulin resistance and dyslipidemia were prevalent in 12% and 25% non-overweight patients respectively. Metabolic syndrome was more common in obese subjects. In addition, magnetic resonance elastography showed higher mean liver fat in the obese group with similar hepatic fibrosis. Non-overweight patients with NAFLD had lower insulin resistance and prevalence of dyslipidaemia at similar dietary and exercise pattern.Scientific reports15232https://www.ebi.ac.uk/biostudies/studies/S-EPMC7499301biostudies-literatureDifference in lifestyle and metabolic profile of non-alcoholic fatty liver disease with raised alanine amino-transferases between obese and non-overweight subjects.PMC7499301Gupta RKulkarni ANori VBJagtap NReddy DNRao PNKumar PSharma MfalseDifference in lifestyle and metabolic profile of non-alcoholic fatty liver disease with raised alanine amino-transferases between obese and non-overweight subjects.A significant proportion of patients with non-alcoholic fatty liver disease (NAFLD) in Asian sub-continent are non-overweight and may have different underlying risk factors, lifestyles and metabolic profiles. Seven hundred fifty patients of NAFLD with raised alanine-amino-transferase (ALT) were divided into non-overweight and obese group based on their body mass index (BMI). Detailed dietary and lifestyle history were obtained through questionnaires and a detailed assessment of metabolic profile and liver stiffness was done. Normal BMI (<?23 kg/m2) was found in 6.6% patients, of which 69.5% had raised ALT. Though the intake of dietary fat and exercise pattern were not different amongst these groups, yet the amount of aerated drinks was higher in obese subjects (12?±?17 vs. 7?±?7.5 p?=?0.005). Serum low-density lipoprotein (111?±?25.6 vs. 127.7?±?32.7 p?=?0.04) and insulin resistance based on HOMA-IR?>?2 were significantly higher in obese group (4.1?±?0.36 vs. 2.0?±?0.15 p?=?0.001). Insulin resistance and dyslipidemia were prevalent in 12% and 25% non-overweight patients respectively. Metabolic syndrome was more common in obese subjects. In addition, magnetic resonance elastography showed higher mean liver fat in the obese group with similar hepatic fibrosis. Non-overweight patients with NAFLD had lower insulin resistance and prevalence of dyslipidaemia at similar dietary and exercise pattern.2020-01-01T00:00:00Z2020 Sep2020-10-09T07:07:36Z2020-09-28T07:02:42ZS-EPMC74993013294374710.1038/s41598-020-72306-x