{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Colavita F"],"funding":["Ministry of Health","European Commission–Horizon 2020"],"pagination":["ofaa403"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7499768"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["<h4>Background</h4>The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy.<h4>Methods</h4>We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. Serological analysis was carried out on serial serum samples to evaluate IgM, IgA, IgG, and neutralizing antibody levels.<h4>Results</h4>SARS-CoV-2 RNA was detected since the early phase of illness, lasting over 2 weeks in both upper and lower respiratory trac"],"journal":["Open forum infectious diseases"],"pubmed_title":["Virological Characterization of the First 2 COVID-19 Patients Diagnosed in Italy: Phylogenetic Analysis, Virus Shedding Profile From Different Body Sites, and Antibody Response Kinetics."],"pmcid":["PMC7499768"],"funding_grant_id":["COVID 2020 12371675","COVID-2020-12371817","101003551","101003544–CoNVat"],"pubmed_authors":["Marchioni L","Apollonio C","Ferraioli V","Benigni M","Felici L","Giombini E","Leone B","Campioni P","Casetti R","Petrosillo N","Biancone S","Amendola A","Pianura E","Vescovo T","Noto R","Passeri V","Scorzolini L","Pittalis S","Garotto G","Matusali G","Venditti C","Aleo L","Bartolini B","Ferraro F","Agrati C","Vulcano A","Castilletti C","Cristofaro M","Turchi F","Macchione M","Rozera G","Dantimi C","Palazzolo C","Petrivelli E","Carletti F","Pallini E","Di Caro A","Sciamanna R","Fabeni L","Rueca M","Lalle E","Brega C","Petruccioli E","Minosse C","Mariano A","Selleri M","Santagata C","Giancola ML","Sanasi F","Ippolito G","Selvaggi C","Fiorentini L","Proietti C","Di Filippo S","Albarello F","Vincenti D","Pelliccioni F","Antonini M","Marani A","Di Giuli C","Branca M","Truffa S","Scarcia S","Sberna G","INMI COVID-19 Laboratory Team and INMI COVID-19 Study Group","Murachelli S","Scognamiglio P","Gruber CEM","Sarti S","D'Abramo A","Arduini N","Coen S","Coppola A","Meschi S","Abbate I","Cannas A","Toffoletti A","Bibbo A","Sabatini R","Garbuglia AR","Abbonizio MA","Cimini E","Galli P","Pizzi D","Ascoli Bartoli T","Raparelli F","Frustaci A","Curiale S","De Angelis G","Bordi L","Forbici F","Prota G","Nicastri E","Khouri D","Stazi G","De Angelis A","Lucia A","Petrecchia A","Berno G","Massimino C","Caravella I","D'Arezzo S","Colavita F","Bevilacqua N","Di Lorenzo R","Vaia F","Pisciotta M","Caporale C","Capobianchi MR","Marini MC","Graziano S","Stellitano C","Schinina V","Condello R","Ciaralli C","Amadei G","Lapa D","Carrara S","Gori C","Giansante F","Sias C","Montaldo C","Neri S","Bordoni V","Greci MC","Sacchi A","Mazzarelli A","Nisii C","Biava M","Ciafrone L","Zambelli E","Barbaro R","Lufrani F","Lepore L","Petrone A","Chiappini R","Puro V","Canali M","Alonzi T","Marsella P","Rinonapoli G","Corpolongo A","Valli MB","Lanini S","Maritti M","Petroni F","Di Stefano F","Vairo F","Messina F"],"additional_accession":[]},"is_claimable":false,"name":"Virological Characterization of the First 2 COVID-19 Patients Diagnosed in Italy: Phylogenetic Analysis, Virus Shedding Profile From Different Body Sites, and Antibody Response Kinetics.","description":"<h4>Background</h4>The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy.<h4>Methods</h4>We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. Serological analysis was carried out on serial serum samples to evaluate IgM, IgA, IgG, and neutralizing antibody levels.<h4>Results</h4>SARS-CoV-2 RNA was detected since the early phase of illness, lasting over 2 weeks in both upper and lower respiratory trac","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-27T01:16:26.913Z","creation":"2021-02-21T06:31:31Z"},"accession":"S-EPMC7499768","cross_references":{"pubmed":["33527081"],"doi":["10.1093/ofid/ofaa403"]}}